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Last Name

Zheng, Pan

InstitutionChildrens National Medical Center
DepartmentCancer & Immunology Research
Address111 Michigan Ave NW
Washington DC 20010
Phone(202) 476-6835
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Du X, Tang F, Liu M, Su J, Zhang Y, Wu W, Devenport M, Lazarski CA, Zhang P, Wang X, Ye P, Wang C, Hwang E, Zhu T, Xu T, Zheng P, Liu Y. A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Cell Res. 2018 Apr; 28(4):416-432. PMID: 29472691.
      View in: PubMed
    2. Du X, Liu M, Su J, Zhang P, Tang F, Ye P, Devenport M, Wang X, Zhang Y, Liu Y, Zheng P. Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice. Cell Res. 2018 Apr; 28(4):433-447. PMID: 29463898.
      View in: PubMed
    3. Li D, Hu M, Liu Y, Ye P, Du P, Li CS, Cheng L, Liu P, Jiang J, Su L, Wang S, Zheng P, Liu Y. CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages. Cell Discov. 2018; 4:6. PMID: 29423273.
      View in: PubMed
    4. Vaughns JD, Conklin LS, Long Y, Zheng P, Faruque F, Green DJ, van den Anker JN, Burckart GJ. Obesity and Pediatric Drug Development. J Clin Pharmacol. 2018 May; 58(5):650-661. PMID: 29350758.
      View in: PubMed
    5. Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y, Zheng P. A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. Elife. 2017 12 05; 6. PMID: 29206103.
      View in: PubMed
    6. Zhang P, Wu X, Basu M, Dong C, Zheng P, Liu Y, Sandler AD. MYCN Amplification Is Associated with Repressed Cellular Immunity in Neuroblastoma: An In Silico Immunological Analysis of TARGET Database. Front Immunol. 2017; 8:1473. PMID: 29163537.
      View in: PubMed
    7. Wang X, Sun B, Liu B, Fu Y, Zheng P. A novel method for multifactorial bio-chemical experiments design based on combinational design theory. PLoS One. 2017; 12(11):e0186853. PMID: 29095845.
      View in: PubMed
    8. Li N, Zheng P, Liu Y. The CD24-Siglec G axis protects mice against cuprizone-induced oligodendrocyte loss: targeting danger signal for neuroprotection. Cell Mol Immunol. 2018 Jan; 15(1):79-81. PMID: 28757612.
      View in: PubMed
    9. Tanno T, Zhang P, Lazarski CA, Liu Y, Zheng P. An aptamer-based targeted delivery of miR-26a protects mice against chemotherapy toxicity while suppressing tumor growth. Blood Adv. 2017 Jun 27; 1(15):1107-1119. PMID: 29296753.
      View in: PubMed
    10. Ichiyama K, Gonzalez-Martin A, Kim BS, Jin HY, Jin W, Xu W, Sabouri-Ghomi M, Xu S, Zheng P, Xiao C, Dong C. The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression. Immunity. 2016 06 21; 44(6):1284-98. PMID: 27332731; PMCID: PMC4918454 [Available on 06/21/17].
    11. Wang X, Song T, Gong F, Zheng P. On the Computational Power of Spiking Neural P Systems with Self-Organization. Sci Rep. 2016 06 10; 6:27624. PMID: 27283843.
      View in: PubMed
    12. Liu Y, Wang Y, Du Z, Yan X, Zheng P, Liu Y. Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5. Cell Rep. 2016 05 03; 15(5):1111-1122. PMID: 27117404; PMCID: PMC4856546.
    13. Li CS, Tang F, Zhang P, Jiang T, Saunders TL, Zheng P, Liu Y. Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development. Cell Mol Immunol. 2017 Aug; 14(8):685-692. PMID: 27063468.
      View in: PubMed
    14. Ichiyama K, Chen T, Wang X, Yan X, Kim BS, Tanaka S, Ndiaye-Lobry D, Deng Y, Zou Y, Zheng P, Tian Q, Aifantis I, Wei L, Dong C. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. Immunity. 2015 Apr 21; 42(4):613-26. PMID: 25862091; PMCID: PMC4956728.
    15. Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L. FOXP3 Controls an miR-146/NF-?B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. Cancer Res. 2015 Apr 15; 75(8):1703-13. PMID: 25712342; PMCID: PMC4706751.
    16. Ye P, Liu Y, Chen C, Tang F, Wu Q, Wang X, Liu CG, Liu X, Liu R, Liu Y, Zheng P. An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. Mol Cell. 2015 Feb 19; 57(4):708-720. PMID: 25639470.
      View in: PubMed
    17. Chen Z, Shen H, Sun C, Yin L, Tang F, Zheng P, Liu Y, Brink R, Rui L. Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. Am J Physiol Endocrinol Metab. 2015 Mar 15; 308(6):E460-9. PMID: 25628422; PMCID: PMC4360016.
    18. Wang L, Liu R, Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W, Zhang P, Jiang T, Bassetti MF, Jube S, Sun Y, Zhang Y, Zheng P, Liu Y. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015 Jan 20; 6:5909. PMID: 25600590; PMCID: PMC4300525.
    19. Wong C, Chen C, Wu Q, Liu Y, Zheng P. A critical role for the regulated wnt-myc pathway in naive T cell survival. J Immunol. 2015 Jan 01; 194(1):158-67. PMID: 25429066; PMCID: PMC4272883.
    20. Chen GY, Brown NK, Wu W, Khedri Z, Yu H, Chen X, van de Vlekkert D, D'Azzo A, Zheng P, Liu Y. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. Elife. 2014 Sep 03; 3:e04066. PMID: 25187624; PMCID: PMC4168287.
    21. Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Elife. 2014 Aug 21; 3:e02236. PMID: 25144937; PMCID: PMC4163686.
    22. Chen GY, Brown NK, Zheng P, Liu Y. Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity. Glycobiology. 2014 Sep; 24(9):800-6. PMID: 24996822; PMCID: PMC4116048.
    23. Wang Y, Liu Y, Tang F, Bernot KM, Schore R, Marcucci G, Caligiuri MA, Zheng P, Liu Y. Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells. Blood. 2014 Aug 14; 124(7):1127-35. PMID: 24994068.
      View in: PubMed
    24. Thaxton JE, Liu B, Zheng P, Liu Y, Li Z. Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. J Immunol. 2014 Jun 15; 192(12):5679-86. PMID: 24808359; PMCID: PMC4185284.
    25. Toubai T, Hou G, Mathewson N, Liu C, Wang Y, Oravecz-Wilson K, Cummings E, Rossi C, Evers R, Sun Y, Wu J, Choi SW, Fang D, Zheng P, Liu Y, Reddy P. Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice. Blood. 2014 May 29; 123(22):3512-23. PMID: 24695850; PMCID: PMC4041170.
    26. Wang Y, Ma K, Wang P, Baba O, Zhang H, Parent JM, Zheng P, Liu Y, Minassian BA, Liu Y. Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons. Mol Neurobiol. 2013 Aug; 48(1):49-61. PMID: 23546741; PMCID: PMC3722335.
    27. Zheng P, Chang X, Lu Q, Liu Y. Cytopenia and autoimmune diseases: a vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells. J Autoimmun. 2013 Mar; 41:182-7. PMID: 23375848; PMCID: PMC3622805.
    28. Chen W, Han C, Xie B, Hu X, Yu Q, Shi L, Wang Q, Li D, Wang J, Zheng P, Liu Y, Cao X. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell. 2013 Jan 31; 152(3):467-78. PMID: 23374343.
      View in: PubMed
    29. Li W, Katoh H, Wang L, Yu X, Du Z, Yan X, Zheng P, Liu Y. FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1. Cancer Res. 2013 Apr 01; 73(7):2170-80. PMID: 23319807; PMCID: PMC3815443.
    30. Katoh H, Zheng P, Liu Y. FOXP3: genetic and epigenetic implications for autoimmunity. J Autoimmun. 2013 Mar; 41:72-8. PMID: 23313429; PMCID: PMC3622774.
    31. Wang L, Liu R, Li D, Lin S, Fang X, Backer G, Kain M, Rammoham K, Zheng P, Liu Y. A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. Am J Transl Res. 2012; 4(3):347-56. PMID: 22937211; PMCID: PMC3426393.
    32. Tang F, Wu Q, Ikenoue T, Guan KL, Liu Y, Zheng P. A critical role for Rictor in T lymphopoiesis. J Immunol. 2012 Aug 15; 189(4):1850-7. PMID: 22815285; PMCID: PMC3412163.
    33. Zeng L, Wang Y, Baba O, Zheng P, Liu Y, Liu Y. Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells. FEBS J. 2012 Jul; 279(14):2467-78. PMID: 22578008; PMCID: PMC3407668.
    34. Ashida S, Orloff MS, Bebek G, Zhang L, Zheng P, Peehl DM, Eng C. Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes. Clin Cancer Res. 2012 Mar 15; 18(6):1578-87. PMID: 22275508.
      View in: PubMed
    35. Zhang X, Liu JQ, Shi Y, Reid HH, Boyd RL, Khattabi M, El-Omrani HY, Zheng P, Liu Y, Bai XF. CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. Eur J Immunol. 2012 Apr; 42(4):924-35. PMID: 22213356; PMCID: PMC3359065.
    36. Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y. FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1. Mol Cell. 2011 Dec 09; 44(5):770-84. PMID: 22152480; PMCID: PMC3243051.
    37. Wang Y, Bruce AT, Tu C, Ma K, Zeng L, Zheng P, Liu Y, Liu Y. Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes. J Cell Sci. 2011 Nov 01; 124(Pt 21):3568-80. PMID: 22045735; PMCID: PMC3215571.
    38. Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, Li W, Guan KL, Liu Y, Zheng P. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol. 2011 Aug 01; 187(3):1106-12. PMID: 21709159.
      View in: PubMed
    39. Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol. 2011 May; 29(5):428-35. PMID: 21478876; PMCID: PMC4090080.
    40. Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. Targeting HIF1a eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 08; 8(4):399-411. PMID: 21474104.
      View in: PubMed
    41. Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011 Mar 15; 71(6):2162-71. PMID: 21278236; PMCID: PMC3070402.
    42. Liu Y, Chen GY, Zheng P. Sialoside-based pattern recognitions discriminating infections from tissue injuries. Curr Opin Immunol. 2011 Feb; 23(1):41-5. PMID: 21208791.
      View in: PubMed
    43. Chen C, Liu Y, Liu Y, Zheng P. Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. J Clin Invest. 2010 Nov; 120(11):4091-101. PMID: 20972332; PMCID: PMC2964994.
    44. Li CS, Chen C, Zheng P, Liu Y. Transgenic expression of P1A induced thymic tumor: a role for onco-fetal antigens in tumorigenesis. PLoS One. 2010 Oct 15; 5(10):e13439. PMID: 20976169; PMCID: PMC2955541.
    45. Wang L, Liu R, Ribick M, Zheng P, Liu Y. FOXP3 as an X-linked tumor suppressor. Discov Med. 2010 Oct; 10(53):322-8. PMID: 21034673; PMCID: PMC4500105.
    46. Katoh H, Zheng P, Liu Y. Signalling through FOXP3 as an X-linked tumor suppressor. Int J Biochem Cell Biol. 2010 Nov; 42(11):1784-7. PMID: 20678582; PMCID: PMC2950213.
    47. Liu Y, Wang L, Zheng P. X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunity. Trends Genet. 2010 Jun; 26(6):260-5. PMID: 20434787; PMCID: PMC2901104.
    48. Liu Y, Chen G, Zheng P, Tang J. On self-nonself discrimination in pattern recognition. Sci China Life Sci. 2010 Feb; 53(2):169-71. PMID: 20596823.
      View in: PubMed
    49. Fang X, Zheng P, Tang J, Liu Y. CD24: from A to Z. Cell Mol Immunol. 2010 Mar; 7(2):100-3. PMID: 20154703.
      View in: PubMed
    50. Chen C, Liu Y, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24; 2(98):ra75. PMID: 19934433; PMCID: PMC4020596.
    51. Wang L, Liu R, Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell. 2009 Oct 06; 16(4):336-46. PMID: 19800578; PMCID: PMC2758294.
    52. Liu Y, Chen GY, Zheng P. CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol. 2009 Dec; 30(12):557-61. PMID: 19786366.
      View in: PubMed
    53. Zhou P, Fang X, McNally BA, Yu P, Zhu M, Fu YX, Wang L, Liu Y, Zheng P. Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17134-9. PMID: 19805094; PMCID: PMC2761305.
    54. Li D, Zheng L, Jin L, Zhou Y, Li H, Fu J, Shi M, Du P, Wang L, Wu H, Chen GY, Zheng P, Liu Y, Wang FS, Wang S. CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. Hepatology. 2009 Sep; 50(3):735-42. PMID: 19610054.
      View in: PubMed
    55. Liu Y, Wang Y, Li W, Zheng P, Liu Y. Activating transcription factor 2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse. Cancer Res. 2009 Jul 15; 69(14):5954-60. PMID: 19584270; PMCID: PMC2742913.
    56. Liu Y, Wang Y, Wu C, Liu Y, Zheng P. Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress. Hum Mol Genet. 2009 Jul 15; 18(14):2622-31. PMID: 19403557; PMCID: PMC2701334.
    57. Chen C, Liu Y, Liu Y, Zheng P. The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells. Cell Cycle. 2009 Apr 15; 8(8):1158-60. PMID: 19270502.
      View in: PubMed
    58. Liu R, Wang L, Chen G, Katoh H, Chen C, Liu Y, Zheng P. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res. 2009 Mar 15; 69(6):2252-9. PMID: 19276356; PMCID: PMC2715174.
    59. Chen GY, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009 Mar 27; 323(5922):1722-5. PMID: 19264983; PMCID: PMC2765686.
    60. Zhou P, Zheng X, Zhang H, Liu Y, Zheng P. B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer. Clin Cancer Res. 2009 Feb 01; 15(3):960-70. PMID: 19188167; PMCID: PMC2693886.
    61. Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K, Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19869-74. PMID: 19073916; PMCID: PMC2604962.
    62. Liu Y, Zheng P. FoxP3: a life beyond regulatory T cells. Int J Clin Exp Pathol. 2009; 2(3):205-10. PMID: 19079616; PMCID: PMC2600463.
    63. Chang X, Zheng P, Liu Y. Selective elimination of autoreactive T cells in vivo by the regulatory T cells. Clin Immunol. 2009 Jan; 130(1):61-73. PMID: 18838339; PMCID: PMC2643025.
    64. Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, Zheng P. Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms. Mol Cell Biol. 2008 Dec; 28(23):7236-44. PMID: 18824542; PMCID: PMC2593373.
    65. Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008 Sep 29; 205(10):2397-408. PMID: 18809716; PMCID: PMC2556783.
    66. Richards J, McNally B, Fang X, Caligiuri MA, Zheng P, Liu Y. Tumor growth decreases NK and B cells as well as common lymphoid progenitor. PLoS One. 2008 Sep 11; 3(9):e3180. PMID: 18784839; PMCID: PMC2527520.
    67. Chang X, Zheng P, Liu Y. Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity. J Immunol. 2008 Aug 15; 181(4):2399-406. PMID: 18684929.
      View in: PubMed
    68. Zheng X, Zhang H, Yin L, Wang CR, Liu Y, Zheng P. Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation. PLoS One. 2008 Jul 16; 3(7):e2703. PMID: 18628995; PMCID: PMC2442875.
    69. Zhang W, Zheng X, Xia C, Perali RS, Yao Q, Liu Y, Zheng P, Wang PG. Alpha-lactosylceramide as a novel "sugar-capped" CD1d ligand for natural killer T cells: biased cytokine profile and therapeutic activities. Chembiochem. 2008 Jun 16; 9(9):1423-30. PMID: 18478523; PMCID: PMC3398384.
    70. Wang Y, Liu Y, Wu C, McNally B, Liu Y, Zheng P. Laforin confers cancer resistance to energy deprivation-induced apoptosis. Cancer Res. 2008 Jun 01; 68(11):4039-44. PMID: 18519661; PMCID: PMC2440919.
    71. McNally BA, Trgovcich J, Maul GG, Liu Y, Zheng P. A role for cytoplasmic PML in cellular resistance to viral infection. PLoS One. 2008 May 28; 3(5):e2277. PMID: 18509536; PMCID: PMC2386554.
    72. Chen GY, Chen C, Wang L, Chang X, Zheng P, Liu Y. Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol. 2008 Apr 15; 180(8):5163-6. PMID: 18390696; PMCID: PMC2527697.
    73. Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu Y. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest. 2007 Dec; 117(12):3765-73. PMID: 18008005; PMCID: PMC2075479.
    74. Liu Y, Zheng P. FOXP3 and breast cancer: implications for therapy and diagnosis. Pharmacogenomics. 2007 Nov; 8(11):1485-7. PMID: 18034612.
      View in: PubMed
    75. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007 Nov 01; 21(21):2747-61. PMID: 17974916; PMCID: PMC2045129.
    76. Ding C, Liu Y, Wang Y, Park BK, Wang CY, Zheng P, Liu Y. Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation. PLoS One. 2007 Oct 03; 2(10):e997. PMID: 17912374; PMCID: PMC1994585.
    77. Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell. 2007 Jun 29; 129(7):1275-86. PMID: 17570480; PMCID: PMC1974845.
    78. Liu Y, Zheng P. CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases. Trends Immunol. 2007 Jul; 28(7):315-20. PMID: 17531534.
      View in: PubMed
    79. Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, Liu RH, Guinther N, Lima J, Zhou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. A dinucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genet. 2007 Apr 06; 3(4):e49. PMID: 17411341; PMCID: PMC1847692.
    80. May KF, Chang X, Zhang H, Lute KD, Zhou P, Kocak E, Zheng P, Liu Y. B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells. J Immunol. 2007 Feb 01; 178(3):1542-52. PMID: 17237403.
      View in: PubMed
    81. Liu Y, Wang Y, Wu C, Liu Y, Zheng P. Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling. J Biol Chem. 2006 Nov 17; 281(46):34768-74. PMID: 16971387.
      View in: PubMed
    82. Wang Y, Liu Y, Wu C, Zhang H, Zheng X, Zheng Z, Geiger TL, Nuovo GJ, Liu Y, Zheng P. Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell. 2006 Sep; 10(3):179-90. PMID: 16959610.
      View in: PubMed
    83. Bai XF, Liu JQ, Joshi PS, Wang L, Yin L, Labanowska J, Heerema N, Zheng P, Liu Y. Different lineages of P1A-expressing cancer cells use divergent modes of immune evasion for T-cell adoptive therapy. Cancer Res. 2006 Aug 15; 66(16):8241-9. PMID: 16912204.
      View in: PubMed
    84. May KF, Lute K, Kocak E, Abdessalam S, Yin L, Li O, Guan Z, Philips G, Zheng P, Liu Y. Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice. Blood. 2007 Jan 01; 109(1):253-8. PMID: 16896159; PMCID: PMC1785073.
    85. Kocak E, Lute K, Chang X, May KF, Exten KR, Zhang H, Abdessalam SF, Lehman AM, Jarjoura D, Zheng P, Liu Y. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res. 2006 Jul 15; 66(14):7276-84. PMID: 16849577.
      View in: PubMed
    86. Li O, Chang X, Zhang H, Kocak E, Ding C, Zheng P, Liu Y. Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts. J Exp Med. 2006 Jul 10; 203(7):1713-20. PMID: 16769998; PMCID: PMC2118348.
    87. Richards JO, Chang X, Blaser BW, Caligiuri MA, Zheng P, Liu Y. Tumor growth impedes natural-killer-cell maturation in the bone marrow. Blood. 2006 Jul 01; 108(1):246-52. PMID: 16556890; PMCID: PMC1895835.
    88. Chang X, Zheng P, Liu Y. FoxP3: a genetic link between immunodeficiency and autoimmune diseases. Autoimmun Rev. 2006 Jul; 5(6):399-402. PMID: 16890893.
      View in: PubMed
    89. Chang X, Gao JX, Jiang Q, Wen J, Seifers N, Su L, Godfrey VL, Zuo T, Zheng P, Liu Y. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med. 2005 Oct 17; 202(8):1141-51. PMID: 16230479; PMCID: PMC2213221.
    90. Lute KD, May KF, Lu P, Zhang H, Kocak E, Mosinger B, Wolford C, Phillips G, Caligiuri MA, Zheng P, Liu Y. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. Blood. 2005 Nov 01; 106(9):3127-33. PMID: 16037385; PMCID: PMC1895337.
    91. Yang T, Lapinski PE, Zhao H, Zhou Q, Zhang H, Raghavan M, Liu Y, Zheng P. A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing. Clin Cancer Res. 2005 May 15; 11(10):3614-23. PMID: 15897556.
      View in: PubMed
    92. Zheng X, Yin L, Liu Y, Zheng P. Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs. Eur J Immunol. 2004 Nov; 34(11):3126-34. PMID: 15368272.
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    93. May KF, Roychowdhury S, Bhatt D, Kocak E, Bai XF, Liu JQ, Ferketich AK, Martin EW, Caligiuri MA, Zheng P, Liu Y. Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies. Blood. 2005 Feb 01; 105(3):1114-20. PMID: 15486062.
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    94. Li O, Zheng P, Liu Y. CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med. 2004 Oct 18; 200(8):1083-9. PMID: 15477346; PMCID: PMC2211842.
    95. Gao JX, Chang X, Zheng X, Wen J, Yin L, Du P, Zheng P, Liu Y. A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen. Int Immunol. 2004 Oct; 16(10):1403-9. PMID: 15314039.
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    96. Bai XF, Li O, Zhou Q, Zhang H, Joshi PS, Zheng X, Liu Y, Wang Y, Zheng P, Liu Y. CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J Exp Med. 2004 Aug 16; 200(4):447-58. PMID: 15314074; PMCID: PMC2211938.
    97. Zheng X, Gao JX, Chang X, Wang Y, Liu Y, Wen J, Zhang H, Zhang J, Liu Y, Zheng P. B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus. J Immunol. 2004 Aug 15; 173(4):2253-61. PMID: 15294937.
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    98. Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X, Bai XF, Yin L, Scarberry B, Du P, You M, Guan K, Zheng P, Liu Y. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15041-6. PMID: 14657362; PMCID: PMC299898.
    99. Sarma S, Bai XF, Liu JQ, May KF, Zheng P, Liu Y. On the role of unmutated antigens in tumor rejection in mice with unperturbed T-cell repertoires. Cancer Res. 2003 Sep 15; 63(18):6051-5. PMID: 14522934.
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    100. Gao JX, Liu X, Wen J, Caligiuri MA, Stroynowski I, Zheng P, Liu Y. Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells. Blood. 2003 Dec 15; 102(13):4456-63. PMID: 12933569.
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    101. Wong AW, Brickey WJ, Taxman DJ, van Deventer HW, Reed W, Gao JX, Zheng P, Liu Y, Li P, Blum JS, McKinnon KP, Ting JP. CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat Immunol. 2003 Sep; 4(9):891-8. PMID: 12910265.
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    102. Liu X, Gao JX, Wen J, Yin L, Li O, Zuo T, Gajewski TF, Fu YX, Zheng P, Liu Y. B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J Exp Med. 2003 Jun 16; 197(12):1721-30. PMID: 12810690; PMCID: PMC2193953.
    103. Gao JX, Liu X, Wen J, Zhang H, Durbin J, Liu Y, Zheng P. Differentiation of monocytic cell clones into CD8 alpha+ dendritic cells (DC) suggests that monocytes can be direct precursors for both CD8 alpha+ and CD8 alpha- DC in the mouse. J Immunol. 2003 Jun 15; 170(12):5927-35. PMID: 12794119.
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    104. Bai XF, Liu J, Li O, Zheng P, Liu Y. Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes. J Clin Invest. 2003 May; 111(10):1487-96. PMID: 12750398; PMCID: PMC155049.
    105. Zhang H, Melamed J, Wei P, Cox K, Frankel W, Bahnson RR, Robinson N, Pyka R, Liu Y, Zheng P. Concordant down-regulation of proto-oncogene PML and major histocompatibility antigen HLA class I expression in high-grade prostate cancer. Cancer Immun. 2003 Feb 14; 3:2. PMID: 12747744.
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    106. Yang T, McNally BA, Ferrone S, Liu Y, Zheng P. A single-nucleotide deletion leads to rapid degradation of TAP-1 mRNA in a melanoma cell line. J Biol Chem. 2003 Apr 25; 278(17):15291-6. PMID: 12582163.
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    107. Zheng X, Gao JX, Zhang H, Geiger TL, Liu Y, Zheng P. Clonal deletion of simian virus 40 large T antigen-specific T cells in the transgenic adenocarcinoma of mouse prostate mice: an important role for clonal deletion in shaping the repertoire of T cells specific for antigens overexpressed in solid tumors. J Immunol. 2002 Nov 01; 169(9):4761-9. PMID: 12391185.
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    108. May KF, Chen L, Zheng P, Liu Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 2002 Jun 15; 62(12):3459-65. PMID: 12067989.
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    109. Bai XF, Liu J, May KF, Guo Y, Zheng P, Liu Y. B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo. Blood. 2002 Apr 15; 99(8):2880-9. PMID: 11929778.
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    110. Gao JX, Zhang H, Bai XF, Wen J, Zheng X, Liu J, Zheng P, Liu Y. Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. J Exp Med. 2002 Apr 15; 195(8):959-71. PMID: 11956287; PMCID: PMC2193695.
    111. Guo Y, Yang T, Liu X, Lu S, Wen J, Durbin JE, Liu Y, Zheng P. Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-gamma-mediated activation of the transcription initiator. Int Immunol. 2002 Feb; 14(2):189-200. PMID: 11809738.
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