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Institution

Nagaraju, Kanneboyina

TitleProfessor
InstitutionChildrens National Medical Center
DepartmentChief Academic Office
Address111 Michigan Ave NW
Washington DC 20010
PhoneNA
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Defour A, Medikayala S, Van der Meulen JH, Hogarth MW, Holdreith N, Malatras A, Duddy W, Boehler J, Nagaraju K, Jaiswal JK. Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle. Hum Mol Genet. 2017 Jun 01; 26(11):1979-1991. PMID: 28334824.
      View in: PubMed
    2. Vila MC, Rayavarapu S, Hogarth MW, Van der Meulen JH, Horn A, Defour A, Takeda S, Brown KJ, Hathout Y, Nagaraju K, Jaiswal JK. Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy. Cell Death Differ. 2017 Feb; 24(2):330-342. PMID: 27834955.
      View in: PubMed
    3. Many GM, Yokosaki Y, Uaesoontrachoon K, Nghiem PP, Bello L, Dadgar S, Yin Y, Damsker JM, Cohen HB, Kornegay JN, Bamman MM, Mosser DM, Nagaraju K, Hoffman EP. OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages. Exp Physiol. 2016 Oct 01; 101(10):1285-1300. PMID: 27452303.
      View in: PubMed
    4. Hathout Y, Conklin LS, Seol H, Gordish-Dressman H, Brown KJ, Morgenroth LP, Nagaraju K, Heier CR, Damsker JM, van den Anker JN, Henricson E, Clemens PR, Mah JK, McDonald C, Hoffman EP. Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children. Sci Rep. 2016 Aug 17; 6:31727. PMID: 27530235; PMCID: PMC4987691.
    5. Munters LA, Loell I, Ossipova E, Raouf J, Dastmalchi M, Lindroos E, Chen YW, Esbjörnsson M, Korotkova M, Alexanderson H, Nagaraju K, Crofford LJ, Jakobsson PJ, Lundberg IE. Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis. Arthritis Rheumatol. 2016 Jul; 68(7):1738-50. PMID: 26867141.
      View in: PubMed
    6. Loell I, Raouf J, Chen YW, Shi R, Nennesmo I, Alexanderson H, Dastmalchi M, Nagaraju K, Korotkova M, Lundberg IE. Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents. Arthritis Res Ther. 2016 Jun 10; 18(1):136. PMID: 27287443; PMCID: PMC4902919.
    7. Benny Klimek ME, Sali A, Rayavarapu S, Van der Meulen JH, Nagaraju K. Effect of the IL-1 Receptor Antagonist Kineret® on Disease Phenotype in mdx Mice. PLoS One. 2016; 11(5):e0155944. PMID: 27213537; PMCID: PMC4877010.
    8. Nagaraju K, Ghimbovschi S, Rayavarapu S, Phadke A, Rider LG, Hoffman EP, Miller FW. Muscle myeloid type I interferon gene expression may predict therapeutic responses to rituximab in myositis patients. Rheumatology (Oxford). 2016 Sep; 55(9):1673-80. PMID: 27215813.
      View in: PubMed
    9. Leikina E, Defour A, Melikov K, Van der Meulen JH, Nagaraju K, Bhuvanendran S, Gebert C, Pfeifer K, Chernomordik LV, Jaiswal JK. Annexin A1 Deficiency does not Affect Myofiber Repair but Delays Regeneration of Injured Muscles. Sci Rep. 2015 Dec 15; 5:18246. PMID: 26667898; PMCID: PMC4678367.
    10. Vila MC, Klimek MB, Novak JS, Rayavarapu S, Uaesoontrachoon K, Boehler JF, Fiorillo AA, Hogarth MW, Zhang A, Shaughnessy C, Gordish-Dressman H, Burki U, Straub V, Lu QL, Partridge TA, Brown KJ, Hathout Y, van den Anker J, Hoffman EP, Nagaraju K. Elusive sources of variability of dystrophin rescue by exon skipping. Skelet Muscle. 2015; 5:44. PMID: 26634117; PMCID: PMC4667482.
    11. Coley WD, Bogdanik L, Vila MC, Yu Q, Van Der Meulen JH, Rayavarapu S, Novak JS, Nearing M, Quinn JL, Saunders A, Dolan C, Andrews W, Lammert C, Austin A, Partridge TA, Cox GA, Lutz C, Nagaraju K. Effect of genetic background on the dystrophic phenotype in mdx mice. Hum Mol Genet. 2016 Jan 01; 25(1):130-45. PMID: 26566673; PMCID: PMC4690497 [Available on 01/01/17].
    12. Peay HL, Scharff H, Tibben A, Wilfond B, Bowie J, Johnson J, Nagaraju K, Escolar D, Piacentino J, Biesecker BB. "Watching time tick by…": Decision making for Duchenne muscular dystrophy trials. Contemp Clin Trials. 2016 Jan; 46:1-6. PMID: 26546066; PMCID: PMC4793403 [Available on 01/01/17].
    13. Albrecht I, Wick C, Hallgren Å, Tjärnlund A, Nagaraju K, Andrade F, Thompson K, Coley W, Phadke A, Diaz-Gallo LM, Bottai M, Nennesmo I, Chemin K, Herrath J, Johansson K, Wikberg A, Ytterberg AJ, Zubarev RA, Danielsson O, Krystufkova O, Vencovsky J, Landegren N, Wahren-Herlenius M, Padyukov L, Kämpe O, Lundberg IE. Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J Clin Invest. 2015 Dec; 125(12):4612-24. PMID: 26551678; PMCID: PMC4665781.
    14. Lightfoot AP, Nagaraju K, McArdle A, Cooper RG. Understanding the origin of non-immune cell-mediated weakness in the idiopathic inflammatory myopathies - potential role of ER stress pathways. Curr Opin Rheumatol. 2015 Nov; 27(6):580-5. PMID: 26335926.
      View in: PubMed
    15. Fu X, Brown KJ, Rayavarapu S, Nagaraju K, Liu JS. The use of proteomic analysis to study trafficking defects in axons. Methods Cell Biol. 2016; 131:151-62. PMID: 26794512.
      View in: PubMed
    16. Fiorillo AA, Heier CR, Novak JS, Tully CB, Brown KJ, Uaesoontrachoon K, Vila MC, Ngheim PP, Bello L, Kornegay JN, Angelini C, Partridge TA, Nagaraju K, Hoffman EP. TNF-a-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy. Cell Rep. 2015 Sep 08; 12(10):1678-90. PMID: 26321630; PMCID: PMC4757433.
    17. Rosenberg AS, Puig M, Nagaraju K, Hoffman EP, Villalta SA, Rao VA, Wakefield LM, Woodcock J. Immune-mediated pathology in Duchenne muscular dystrophy. Sci Transl Med. 2015 Aug 05; 7(299):299rv4. PMID: 26246170.
      View in: PubMed
    18. Dillingham BC, Benny Klimek ME, Gernapudi R, Rayavarapu S, Gallardo E, Van der Meulen JH, Jordan S, Ampong B, Gordish-Dressman H, Spurney CF, Nagaraju K. Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice. J Neurol Sci. 2015 Sep 15; 356(1-2):157-62. PMID: 26119397; PMCID: PMC4545396.
    19. Willmann R, Luca A, Nagaraju K, Rüegg MA. Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. J Neuromuscul Dis. 2015 May 14; 2(2):113-117. PMID: 27858730.
      View in: PubMed
    20. Duddy W, Duguez S, Johnston H, Cohen TV, Phadke A, Gordish-Dressman H, Nagaraju K, Gnocchi V, Low S, Partridge T. Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia. Skelet Muscle. 2015; 5:16. PMID: 25987977; PMCID: PMC4434871.
    21. Heslop E, Csimma C, Straub V, McCall J, Nagaraju K, Wagner KR, Caizergues D, Korinthenberg R, Flanigan KM, Kaufmann P, McNeil E, Mendell J, Hesterlee S, Wells DJ, Bushby K. The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development. Orphanet J Rare Dis. 2015 Apr 23; 10:49. PMID: 25902795; PMCID: PMC4417237.
    22. Echigoya Y, Aoki Y, Miskew B, Panesar D, Touznik A, Nagata T, Tanihata J, Nakamura A, Nagaraju K, Yokota T. Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice. Mol Ther Nucleic Acids. 2015 Feb 03; 4:e225. PMID: 25647512; PMCID: PMC4345310.
    23. Zhang A, Uaesoontrachoon K, Shaughnessy C, Das JR, Rayavarapu S, Brown KJ, Ray PE, Nagaraju K, van den Anker JN, Hoffman EP, Hathout Y. The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse. Toxicol Rep. 2015; 2:838-849. PMID: 26213685.
      View in: PubMed
    24. Dillingham BC, Knoblach SM, Many GM, Harmon BT, Mullen AM, Heier CR, Bello L, McCall JM, Hoffman EP, Connor EM, Nagaraju K, Reeves EKM, Damsker JM. VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis. Cell Mol Neurobiol. 2015 Apr; 35(3):377-387. PMID: 25392236.
      View in: PubMed
    25. Heier CR, Guerron AD, Korotcov A, Lin S, Gordish-Dressman H, Fricke S, Sze RW, Hoffman EP, Wang P, Nagaraju K. Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits. PLoS One. 2014; 9(11):e112477. PMID: 25390038; PMCID: PMC4229202.
    26. Dadgar S, Wang Z, Johnston H, Kesari A, Nagaraju K, Chen YW, Hill DA, Partridge TA, Giri M, Freishtat RJ, Nazarian J, Xuan J, Wang Y, Hoffman EP. Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy. J Cell Biol. 2014 Oct 13; 207(1):139-58. PMID: 25313409; PMCID: PMC4195829.
    27. Tatem KS, Quinn JL, Phadke A, Yu Q, Gordish-Dressman H, Nagaraju K. Behavioral and locomotor measurements using an open field activity monitoring system for skeletal muscle diseases. J Vis Exp. 2014 Sep 29; (91):51785. PMID: 25286313; PMCID: PMC4672952.
    28. Alcala SE, Benton AS, Watson AM, Kureshi S, Reeves EM, Damsker J, Wang Z, Nagaraju K, Anderson J, Williams AM, Lee AJ, Hayes K, Rose MC, Hoffman EP, Freishtat RJ. Mitotic asynchrony induces transforming growth factor-ß1 secretion from airway epithelium. Am J Respir Cell Mol Biol. 2014 Sep; 51(3):363-9. PMID: 24669775; PMCID: PMC4189490.
    29. Hathout Y, Marathi RL, Rayavarapu S, Zhang A, Brown KJ, Seol H, Gordish-Dressman H, Cirak S, Bello L, Nagaraju K, Partridge T, Hoffman EP, Takeda S, Mah JK, Henricson E, McDonald C. Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. Hum Mol Genet. 2014 Dec 15; 23(24):6458-69. PMID: 25027324; PMCID: PMC4240201.
    30. Varadkar P, Despres D, Kraman M, Lozier J, Phadke A, Nagaraju K, Mccright B. The protein phosphatase 2A B56? regulatory subunit is required for heart development. Dev Dyn. 2014 Jun; 243(6):778-90. PMID: 24425002.
      View in: PubMed
    31. Uaesoontrachoon K, Quinn JL, Tatem KS, Van Der Meulen JH, Yu Q, Phadke A, Miller BK, Gordish-Dressman H, Ongini E, Miglietta D, Nagaraju K. Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy. Hum Mol Genet. 2014 Jun 15; 23(12):3239-49. PMID: 24463621; PMCID: PMC4030778.
    32. Kornegay JN, Spurney CF, Nghiem PP, Brinkmeyer-Langford CL, Hoffman EP, Nagaraju K. Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. ILAR J. 2014; 55(1):119-49. PMID: 24936034; PMCID: PMC4158345.
    33. Henriques-Pons A, Yu Q, Rayavarapu S, Cohen TV, Ampong B, Cha HJ, Jahnke V, Van der Meulen J, Wang D, Jiang W, Kandimalla ER, Agrawal S, Spurney CF, Nagaraju K. Role of Toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle. Hum Mol Genet. 2014 May 15; 23(10):2604-17. PMID: 24368419; PMCID: PMC3990161.
    34. Rayavarapu S, Coley W, Van der Meulen JH, Cakir E, Tappeta K, Kinder TB, Dillingham BC, Brown KJ, Hathout Y, Nagaraju K. Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target. Arthritis Rheum. 2013 Dec; 65(12):3248-58. PMID: 24022788; PMCID: PMC4080828.
    35. Huynh T, Uaesoontrachoon K, Quinn JL, Tatem KS, Heier CR, Van Der Meulen JH, Yu Q, Harris M, Nolan CJ, Haegeman G, Grounds MD, Nagaraju K. Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice. J Pathol. 2013 Oct; 231(2):223-35. PMID: 23794417; PMCID: PMC4104819.
    36. Uaesoontrachoon K, Cha HJ, Ampong B, Sali A, Vandermeulen J, Wei B, Creeden B, Huynh T, Quinn J, Tatem K, Rayavarapu S, Hoffman EP, Nagaraju K. The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands. J Pathol. 2013 Oct; 231(2):199-209. PMID: 23857504; PMCID: PMC4071457.
    37. Heier CR, Damsker JM, Yu Q, Dillingham BC, Huynh T, Van der Meulen JH, Sali A, Miller BK, Phadke A, Scheffer L, Quinn J, Tatem K, Jordan S, Dadgar S, Rodriguez OC, Albanese C, Calhoun M, Gordish-Dressman H, Jaiswal JK, Connor EM, McCall JM, Hoffman EP, Reeves EK, Nagaraju K. VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects. EMBO Mol Med. 2013 10; 5(10):1569-85. PMID: 24014378; PMCID: PMC3799580.
    38. Sali A, Many GM, Gordish-Dressman H, van der Meulen JH, Phadke A, Spurney CF, Cnaan A, Hoffman EP, Nagaraju K. The proton pump inhibitor lansoprazole improves the skeletal phenotype in dystrophin deficient mdx mice. PLoS One. 2013; 8(7):e66617. PMID: 23843959; PMCID: PMC3699610.
    39. Coley W, Rayavarapu S, van der Meulen JH, Duba AS, Nagaraju K. Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis. PLoS One. 2013; 8(6):e65970. PMID: 23785461; PMCID: PMC3681851.
    40. Rayavarapu S, Coley W, Kinder TB, Nagaraju K. Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness. Skelet Muscle. 2013 Jun 07; 3(1):13. PMID: 23758833; PMCID: PMC3681571.
    41. Yu Q, Sali A, Van der Meulen J, Creeden BK, Gordish-Dressman H, Rutkowski A, Rayavarapu S, Uaesoontrachoon K, Huynh T, Nagaraju K, Spurney CF. Omigapil treatment decreases fibrosis and improves respiratory rate in dy(2J) mouse model of congenital muscular dystrophy. PLoS One. 2013; 8(6):e65468. PMID: 23762378; PMCID: PMC3675144.
    42. Damsker JM, Dillingham BC, Rose MC, Balsley MA, Heier CR, Watson AM, Stemmy EJ, Jurjus RA, Huynh T, Tatem K, Uaesoontrachoon K, Berry DM, Benton AS, Freishtat RJ, Hoffman EP, McCall JM, Gordish-Dressman H, Constant SL, Reeves EK, Nagaraju K. VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice. PLoS One. 2013; 8(5):e63871. PMID: 23667681; PMCID: PMC3646769.
    43. Reeves EKM, Hoffman EP, Nagaraju K, Damsker JM, McCall JM. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem. 2013 Apr 15; 21(8):2241-2249. PMID: 23498916; PMCID: PMC4088988.
    44. Takanohashi A, Prust M, Wang J, Gordish-Dressman H, Bloom M, Rice GI, Schmidt JL, Crow YJ, Lebon P, Kuijpers TW, Nagaraju K, Vanderver A. Elevation of proinflammatory cytokines in patients with Aicardi-Goutières syndrome. Neurology. 2013 Mar 12; 80(11):997-1002. PMID: 23408864; PMCID: PMC3653200.
    45. Rayavarapu S, Coley W, Cakir E, Jahnke V, Takeda S, Aoki Y, Grodish-Dressman H, Jaiswal JK, Hoffman EP, Brown KJ, Hathout Y, Nagaraju K. Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse. Mol Cell Proteomics. 2013 May; 12(5):1061-73. PMID: 23297347; PMCID: PMC3650321.
    46. Brown KJ, Marathi R, Fiorillo AA, Ciccimaro EF, Sharma S, Rowlands DS, Rayavarapu S, Nagaraju K, Hoffman EP, Hathout Y. Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry. J Bioanal Biomed. 2012 Dec 18; Suppl 7. PMID: 23646235.
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    47. Hoffman EP, Reeves E, Damsker J, Nagaraju K, McCall JM, Connor EM, Bushby K. Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy. Phys Med Rehabil Clin N Am. 2012 Nov; 23(4):821-8. PMID: 23137739; PMCID: PMC3606917.
    48. Coley W, Rayavarapu S, Pandey GS, Sabina RL, Van der Meulen JH, Ampong B, Wortmann RL, Rawat R, Nagaraju K. The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy. Arthritis Rheum. 2012 Nov; 64(11):3750-9. PMID: 22806328; PMCID: PMC3485437.
    49. Jahnke VE, Van Der Meulen JH, Johnston HK, Ghimbovschi S, Partridge T, Hoffman EP, Nagaraju K. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model. Skelet Muscle. 2012 Aug 21; 2(1):16. PMID: 22908954; PMCID: PMC3482394.
    50. Aoki Y, Yokota T, Nagata T, Nakamura A, Tanihata J, Saito T, Duguez SM, Nagaraju K, Hoffman EP, Partridge T, Takeda S. Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13763-8. PMID: 22869723; PMCID: PMC3427064.
    51. Sharron M, Hoptay CE, Wiles AA, Garvin LM, Geha M, Benton AS, Nagaraju K, Freishtat RJ. Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade. PLoS One. 2012; 7(7):e41549. PMID: 22844498; PMCID: PMC3406039.
    52. Rutkowski A, Bönnemann C, Brown S, Thorsteinsdóttir S, Dominov J, Ruegg MA, Matter ML, Guttridge D, Crosbie-Watson RH, Kardon G, Nagaraju K, Girgenrath M, Burkin DJ. Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA. Neuromuscul Disord. 2013 Feb; 23(2):188-91. PMID: 22800409.
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    53. Baudy AR, Reeves EK, Damsker JM, Heier C, Garvin LM, Dillingham BC, McCall J, Rayavarapu S, Wang Z, Vandermeulen JH, Sali A, Jahnke V, Duguez S, DuBois D, Rose MC, Nagaraju K, Hoffman EP. ?-9,11 modification of glucocorticoids dissociates nuclear factor-?B inhibitory efficacy from glucocorticoid response element-associated side effects. J Pharmacol Exp Ther. 2012 Oct; 343(1):225-32. PMID: 22743576; PMCID: PMC3464029.
    54. Kostek MC, Nagaraju K, Pistilli E, Sali A, Lai SH, Gordon B, Chen YW. IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse. BMC Musculoskelet Disord. 2012 Jun 20; 13:106. PMID: 22716658; PMCID: PMC3522537.
    55. Rayavarapu S, Coley W, Nagaraju K. Endoplasmic reticulum stress in skeletal muscle homeostasis and disease. Curr Rheumatol Rep. 2012 Jun; 14(3):238-43. PMID: 22410828; PMCID: PMC3587844.
    56. Pandey SN, Cabotage J, Shi R, Dixit M, Sutherland M, Liu J, Muger S, Harper SQ, Nagaraju K, Chen YW. Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice. Biol Open. 2012 Jul; 1(7):629-639. PMID: 23125914.
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    57. Coley W, Rayavarapu S, Nagaraju K. Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies. Arthritis Res Ther. 2012 Apr 27; 14(2):209. PMID: 22546362; PMCID: PMC3446443.
    58. Sali A, Guerron AD, Gordish-Dressman H, Spurney CF, Iantorno M, Hoffman EP, Nagaraju K. Glucocorticoid-treated mice are an inappropriate positive control for long-term preclinical studies in the mdx mouse. PLoS One. 2012; 7(4):e34204. PMID: 22509280; PMCID: PMC3317932.
    59. Reeves EK, Rayavarapu S, Damsker JM, Nagaraju K. Glucocorticoid analogues: potential therapeutic alternatives for treating inflammatory muscle diseases. Endocr Metab Immune Disord Drug Targets. 2012 Mar; 12(1):95-103. PMID: 22214335.
      View in: PubMed
    60. Alger HM, Raben N, Pistilli E, Francia DL, Rawat R, Getnet D, Ghimbovschi S, Chen YW, Lundberg IE, Nagaraju K. The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage. Arthritis Rheum. 2011 Nov; 63(11):3448-57. PMID: 21769834; PMCID: PMC3203318.
    61. Rayavarapu S, Coley W, Nagaraju K. An update on pathogenic mechanisms of inflammatory myopathies. Curr Opin Rheumatol. 2011 Nov; 23(6):579-84. PMID: 21960036.
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    62. Humphrey GW, Mekhedov E, Blank PS, de Morree A, Pekkurnaz G, Nagaraju K, Zimmerberg J. GREG cells, a dysferlin-deficient myogenic mouse cell line. Exp Cell Res. 2012 Jan 15; 318(2):127-35. PMID: 22020321; PMCID: PMC3541016.
    63. Willmann R, De Luca A, Benatar M, Grounds M, Dubach J, Raymackers JM, Nagaraju K. Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice. Neuromuscul Disord. 2012 Jan; 22(1):43-9. PMID: 21737275; PMCID: PMC3227750.
    64. Baudy AR, Sali A, Jordan S, Kesari A, Johnston HK, Hoffman EP, Nagaraju K. Non-invasive optical imaging of muscle pathology in mdx mice using cathepsin caged near-infrared imaging. Mol Imaging Biol. 2011 Jun; 13(3):462-470. PMID: 20661652; PMCID: PMC3087873.
    65. Spurney CF, Guerron AD, Yu Q, Sali A, van der Meulen JH, Hoffman EP, Nagaraju K. Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice. BMC Cardiovasc Disord. 2011 May 16; 11:20. PMID: 21575230; PMCID: PMC3123649.
    66. Nagaraju K, Lundberg IE. Polymyositis and dermatomyositis: pathophysiology. Rheum Dis Clin North Am. 2011 May; 37(2):159-71, v. PMID: 21444017.
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    67. Spurney CF, Sali A, Guerron AD, Iantorno M, Yu Q, Gordish-Dressman H, Rayavarapu S, van der Meulen J, Hoffman EP, Nagaraju K. Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. J Cardiovasc Pharmacol Ther. 2011 Mar; 16(1):87-95. PMID: 21304057; PMCID: PMC4147941.
    68. Alger HM, Rayavarapu S, Nagaraju K. Measurement of activation of the endoplasmic reticulum stress response in autoimmune myositis. Methods Enzymol. 2011; 489:207-25. PMID: 21266232.
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    69. Wu B, Xiao B, Cloer C, Shaban M, Sali A, Lu P, Li J, Nagaraju K, Xiao X, Lu QL. One-year treatment of morpholino antisense oligomer improves skeletal and cardiac muscle functions in dystrophic mdx mice. Mol Ther. 2011 Mar; 19(3):576-83. PMID: 21179007; PMCID: PMC3048192.
    70. Raben N, Schreiner C, Baum R, Takikita S, Xu S, Xie T, Myerowitz R, Komatsu M, Van der Meulen JH, Nagaraju K, Ralston E, Plotz PH. Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease. Autophagy. 2010 Nov; 6(8):1078-89. PMID: 20861693; PMCID: PMC3039718.
    71. Rayavarapu S, Van der Meulen JH, Gordish-Dressman H, Hoffman EP, Nagaraju K, Knoblach SM. Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype. PLoS One. 2010 Sep 24; 5(9):e12981. PMID: 20886045; PMCID: PMC2945315.
    72. Nader GA, Dastmalchi M, Alexanderson H, Grundtman C, Gernapudi R, Esbjörnsson M, Wang Z, Rönnelid J, Hoffman EP, Nagaraju K, Lundberg IE. A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis. Mol Med. 2010 Nov-Dec; 16(11-12):455-64. PMID: 20809047; PMCID: PMC2972393.
    73. Guerron AD, Rawat R, Sali A, Spurney CF, Pistilli E, Cha HJ, Pandey GS, Gernapudi R, Francia D, Farajian V, Escolar DM, Bossi L, Becker M, Zerr P, de la Porte S, Gordish-Dressman H, Partridge T, Hoffman EP, Nagaraju K. Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy. PLoS One. 2010 Jun 21; 5(6):e11220. PMID: 20574530; PMCID: PMC2888587.
    74. Rawat R, Cohen TV, Ampong B, Francia D, Henriques-Pons A, Hoffman EP, Nagaraju K. Inflammasome up-regulation and activation in dysferlin-deficient skeletal muscle. Am J Pathol. 2010 Jun; 176(6):2891-900. PMID: 20413686; PMCID: PMC2877850.
    75. Spurney CF, Cha HJ, Sali A, Pandey GS, Pistilli E, Guerron AD, Gordish-Dressman H, Hoffman EP, Nagaraju K. Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PLoS One. 2010 Jan 29; 5(1):e8976. PMID: 20126456; PMCID: PMC2813286.
    76. Freishtat RJ, Nagaraju K, Jusko W, Hoffman EP. Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation. J Investig Med. 2010 Jan; 58(1):19-22. PMID: 19730133; PMCID: PMC3324850.
    77. Henriques-Pons A, Nagaraju K. Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis. Curr Opin Rheumatol. 2009 Nov; 21(6):581-7. PMID: 19713850; PMCID: PMC2877394.
    78. Li CK, Knopp P, Moncrieffe H, Singh B, Shah S, Nagaraju K, Varsani H, Gao B, Wedderburn LR. Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis. Am J Pathol. 2009 Sep; 175(3):1030-40. PMID: 19700752; PMCID: PMC2731122.
    79. Baudy AR, Saxena N, Gordish H, Hoffman EP, Nagaraju K. A robust in vitro screening assay to identify NF-kappaB inhibitors for inflammatory muscle diseases. Int Immunopharmacol. 2009 Sep; 9(10):1209-14. PMID: 19596085; PMCID: PMC2745946.
    80. Nagaraju K, Willmann R. Developing standard procedures for murine and canine efficacy studies of DMD therapeutics: report of two expert workshops on "Pre-clinical testing for Duchenne dystrophy": Washington DC, October 27th-28th 2007 and Zürich, June 30th-July 1st 2008. Neuromuscul Disord. 2009 Jul; 19(7):502-6. PMID: 19560356; PMCID: PMC2766092.
    81. Salomonsson S, Grundtman C, Zhang SJ, Lanner JT, Li C, Katz A, Wedderburn LR, Nagaraju K, Lundberg IE, Westerblad H. Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle. Muscle Nerve. 2009 May; 39(5):674-82. PMID: 19229963; PMCID: PMC2667561.
    82. Spurney CF, Gordish-Dressman H, Guerron AD, Sali A, Pandey GS, Rawat R, Van Der Meulen JH, Cha HJ, Pistilli EE, Partridge TA, Hoffman EP, Nagaraju K. Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures. Muscle Nerve. 2009 May; 39(5):591-602. PMID: 19260102; PMCID: PMC4116326.
    83. Kesari A, Fukuda M, Knoblach S, Bashir R, Nader GA, Rao D, Nagaraju K, Hoffman EP. Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset. Am J Pathol. 2008 Nov; 173(5):1476-87. PMID: 18832576; PMCID: PMC2570137.
    84. Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL. Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):14814-9. PMID: 18806224; PMCID: PMC2546441.
    85. Mintz M, Vanderver A, Brown KJ, Lin J, Wang Z, Kaneski C, Schiffmann R, Nagaraju K, Hoffman EP, Hathout Y. Time series proteome profiling to study endoplasmic reticulum stress response. J Proteome Res. 2008 Jun; 7(6):2435-44. PMID: 18435558; PMCID: PMC4154506.
    86. Spurney CF, Knoblach S, Pistilli EE, Nagaraju K, Martin GR, Hoffman EP. Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart. Neuromuscul Disord. 2008 May; 18(5):371-81. PMID: 18440230; PMCID: PMC2430663.
    87. Grounds MD, Radley HG, Lynch GS, Nagaraju K, De Luca A. Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy. Neurobiol Dis. 2008 Jul; 31(1):1-19. PMID: 18499465; PMCID: PMC2518169.
    88. Nagaraju K, Rawat R, Veszelovszky E, Thapliyal R, Kesari A, Sparks S, Raben N, Plotz P, Hoffman EP. Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B. Am J Pathol. 2008 Mar; 172(3):774-85. PMID: 18276788; PMCID: PMC2258254.
    89. Freishtat RJ, Mojgani B, Nazemzadeh M, Nagaraju K, Hoffman EP. NKG2A inhibits TH2 cell effector function in vitro. BMC Pulm Med. 2007 Oct 10; 7:14. PMID: 17927829; PMCID: PMC2174509.
    90. Raben N, Takikita S, Pittis MG, Bembi B, Marie SK, Roberts A, Page L, Kishnani PS, Schoser BG, Chien YH, Ralston E, Nagaraju K, Plotz PH. Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand... Autophagy. 2007 Nov-Dec; 3(6):546-52. PMID: 17592248.
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    91. Yokota T, Pistilli E, Duddy W, Nagaraju K. Potential of oligonucleotide-mediated exon-skipping therapy for Duchenne muscular dystrophy. Expert Opin Biol Ther. 2007 Jun; 7(6):831-42. PMID: 17555369.
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    92. Shelton GD, Hoffman EP, Ghimbovschi S, Peters IR, Day MJ, Mullins M, Moore PF, Nagaraju K. Immunopathogenic pathways in canine inflammatory myopathies resemble human myositis. Vet Immunol Immunopathol. 2006 Sep 15; 113(1-2):200-14. PMID: 16797723.
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    93. Lamason R, Zhao P, Rawat R, Davis A, Hall JC, Chae JJ, Agarwal R, Cohen P, Rosen A, Hoffman EP, Nagaraju K. Sexual dimorphism in immune response genes as a function of puberty. BMC Immunol. 2006 Feb 22; 7:2. PMID: 16504066; PMCID: PMC1402325.
    94. Nagaraju K, Rider LG, Fan C, Chen YW, Mitsak M, Rawat R, Patterson K, Grundtman C, Miller FW, Plotz PH, Hoffman E, Lundberg IE. Endothelial cell activation and neovascularization are prominent in dermatomyositis. J Autoimmune Dis. 2006 Feb 20; 3:2. PMID: 16504012; PMCID: PMC1397829.
    95. Nagaraju K. Role of major histocompatibility complex class I molecules in autoimmune myositis. Curr Opin Rheumatol. 2005 Nov; 17(6):725-30. PMID: 16224250.
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    96. Nagaraju K, Casciola-Rosen L, Lundberg I, Rawat R, Cutting S, Thapliyal R, Chang J, Dwivedi S, Mitsak M, Chen YW, Plotz P, Rosen A, Hoffman E, Raben N. Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis Rheum. 2005 Jun; 52(6):1824-35. PMID: 15934115.
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    97. Casciola-Rosen L, Nagaraju K, Plotz P, Wang K, Levine S, Gabrielson E, Corse A, Rosen A. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med. 2005 Feb 21; 201(4):591-601. PMID: 15728237; PMCID: PMC2213068.
    98. Raben N, Fukuda T, Gilbert AL, de Jong D, Thurberg BL, Mattaliano RJ, Meikle P, Hopwood JJ, Nagashima K, Nagaraju K, Plotz PH. Replacing acid alpha-glucosidase in Pompe disease: recombinant and transgenic enzymes are equipotent, but neither completely clears glycogen from type II muscle fibers. Mol Ther. 2005 Jan; 11(1):48-56. PMID: 15585405.
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    99. Davies A, Lopez-Briones S, Ong H, O'Neil-Marshall C, Lemonnier FA, Nagaraju K, Metcalf ES, Soloski MJ. Infection-induced expansion of a MHC Class Ib-dependent intestinal intraepithelial gammadelta T cell subset. J Immunol. 2004 Jun 01; 172(11):6828-37. PMID: 15153501.
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    100. Raben N, Nagaraju K, Lee A, Lu N, Rivera Y, Jatkar T, Hopwood JJ, Plotz PH. Induction of tolerance to a recombinant human enzyme, acid alpha-glucosidase, in enzyme deficient knockout mice. Transgenic Res. 2003 Apr; 12(2):171-8. PMID: 12739885.
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    101. Raben N, Jatkar T, Lee A, Lu N, Dwivedi S, Nagaraju K, Plotz PH. Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme. Mol Ther. 2002 Nov; 6(5):601-8. PMID: 12409258.
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    102. Nagaraju K, Plotz PH. Animal models of myositis. Rheum Dis Clin North Am. 2002 Nov; 28(4):917-33. PMID: 12506778.
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    103. Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med. 2002 Sep 16; 196(6):781-91. PMID: 12235211; PMCID: PMC2194054.
    104. Bakay M, Chen YW, Borup R, Zhao P, Nagaraju K, Hoffman EP. Sources of variability and effect of experimental approach on expression profiling data interpretation. BMC Bioinformatics. 2002; 3:4. PMID: 11936955; PMCID: PMC65691.
    105. Casciola-Rosen L, Nagaraju K. Immunoblotting of single cell types isolated from frozen sections by laser microdissection. Methods Enzymol. 2002; 356:70-9. PMID: 12418189.
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