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Last Name

Hathout, Yetrib

TitleAssociate Professor
InstitutionChildrens National Medical Center
DepartmentCenter for Genetic Medicine
Address111 Michigan Ave NW
Washington DC 20010
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA. Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. Nat Commun. 2018 Jan 15; 9(1):208. PMID: 29335405.
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    2. Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA. Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. Nat Commun. 2017 10 16; 8(1):941. PMID: 29038471.
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    3. Anderson J, Seol H, Gordish-Dressman H, Hathout Y, Spurney CF. Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy. Pediatr Cardiol. 2017 Dec; 38(8):1606-1612. PMID: 28821969.
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    4. Vila MC, Rayavarapu S, Hogarth MW, Van der Meulen JH, Horn A, Defour A, Takeda S, Brown KJ, Hathout Y, Nagaraju K, Jaiswal JK. Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy. Cell Death Differ. 2017 Feb; 24(2):330-342. PMID: 27834955.
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    5. Heier CR, Fiorillo AA, Chaisson E, Gordish-Dressman H, Hathout Y, Damsker JM, Hoffman EP, Conklin LS. Identification of Pathway-Specific Serum Biomarkers of Response to Glucocorticoid and Infliximab Treatment in Children with Inflammatory Bowel Disease. Clin Transl Gastroenterol. 2016 Sep 15; 7(9):e192. PMID: 27628422.
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    6. Hathout Y, Conklin LS, Seol H, Gordish-Dressman H, Brown KJ, Morgenroth LP, Nagaraju K, Heier CR, Damsker JM, van den Anker JN, Henricson E, Clemens PR, Mah JK, McDonald C, Hoffman EP. Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children. Sci Rep. 2016 08 17; 6:31727. PMID: 27530235.
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    7. Sharma V, Pandey SN, Khawaja H, Brown KJ, Hathout Y, Chen YW. PARP1 Differentially Interacts with Promoter region of DUX4 Gene in FSHD Myoblasts. J Genet Syndr Gene Ther. 2016 Aug; 7(4). PMID: 27722032.
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    8. Boca SM, Nishida M, Harris M, Rao S, Cheema AK, Gill K, Wang D, An L, Gauba R, Seol H, Morgenroth LP, Henricson E, McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S. Correction: Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study. PLoS One. 2016; 11(7):e0159895. PMID: 27434074.
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    9. Boca SM, Nishida M, Harris M, Rao S, Cheema AK, Gill K, Seol H, Morgenroth LP, Henricson E, McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S. Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study. PLoS One. 2016; 11(4):e0153461. PMID: 27082433; PMCID: PMC4833348.
    10. Hathout Y, Seol H, Han MH, Zhang A, Brown KJ, Hoffman EP. Clinical utility of serum biomarkers in Duchenne muscular dystrophy. Clin Proteomics. 2016; 13:9. PMID: 27051355; PMCID: PMC4820909.
    11. Vila MC, Klimek MB, Novak JS, Rayavarapu S, Uaesoontrachoon K, Boehler JF, Fiorillo AA, Hogarth MW, Zhang A, Shaughnessy C, Gordish-Dressman H, Burki U, Straub V, Lu QL, Partridge TA, Brown KJ, Hathout Y, van den Anker J, Hoffman EP, Nagaraju K. Elusive sources of variability of dystrophin rescue by exon skipping. Skelet Muscle. 2015; 5:44. PMID: 26634117; PMCID: PMC4667482.
    12. Hathout Y. Proteomic methods for biomarker discovery and validation. Are we there yet? Expert Rev Proteomics. 2015 Aug; 12(4):329-31. PMID: 26186709.
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    13. Perazzo S, Soler-García ÁA, Hathout Y, Das JR, Ray PE. Urinary biomarkers of kidney diseases in HIV-infected children. Proteomics Clin Appl. 2015 Jun; 9(5-6):490-500. PMID: 25764519.
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    14. Hathout Y, Brody E, Clemens PR, Cripe L, DeLisle RK, Furlong P, Gordish-Dressman H, Hache L, Henricson E, Hoffman EP, Kobayashi YM, Lorts A, Mah JK, McDonald C, Mehler B, Nelson S, Nikrad M, Singer B, Steele F, Sterling D, Sweeney HL, Williams S, Gold L. Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7153-8. PMID: 26039989; PMCID: PMC4466703.
    15. Zhang A, Uaesoontrachoon K, Shaughnessy C, Das JR, Rayavarapu S, Brown KJ, Ray PE, Nagaraju K, van den Anker JN, Hoffman EP, Hathout Y. The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse. Toxicol Rep. 2015; 2:838-849. PMID: 26213685.
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    16. Murad N, Kokkinaki M, Gunawardena N, Gunawan MS, Hathout Y, Janczura KJ, Theos AC, Golestaneh N. miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration. FEBS J. 2014 Dec; 281(23):5251-64. PMID: 25251993.
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    17. Rowlands DS, Page RA, Sukala WR, Giri M, Ghimbovschi SD, Hayat I, Cheema BS, Lys I, Leikis M, Sheard PW, Wakefield SJ, Breier B, Hathout Y, Brown K, Marathi R, Orkunoglu-Suer FE, Devaney JM, Leiken B, Many G, Krebs J, Hopkins WG, Hoffman EP. Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiol Genomics. 2014 Oct 15; 46(20):747-65. PMID: 25138607; PMCID: PMC4200377.
    18. Hathout Y, Marathi RL, Rayavarapu S, Zhang A, Brown KJ, Seol H, Gordish-Dressman H, Cirak S, Bello L, Nagaraju K, Partridge T, Hoffman EP, Takeda S, Mah JK, Henricson E, McDonald C. Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. Hum Mol Genet. 2014 Dec 15; 23(24):6458-69. PMID: 25027324; PMCID: PMC4240201.
    19. Pillai DK, Sankoorikal BJ, Johnson E, Seneviratne AN, Zurko J, Brown KJ, Hathout Y, Rose MC. Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):292-300. PMID: 24010916; PMCID: PMC3930950.
    20. Rayavarapu S, Coley W, Van der Meulen JH, Cakir E, Tappeta K, Kinder TB, Dillingham BC, Brown KJ, Hathout Y, Nagaraju K. Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target. Arthritis Rheum. 2013 Dec; 65(12):3248-58. PMID: 24022788; PMCID: PMC4080828.
    21. Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51. PMID: 23764502; PMCID: PMC3790302.
    22. Brown KJ, Seol H, Pillai DK, Sankoorikal BJ, Formolo CA, Mac J, Edwards NJ, Rose MC, Hathout Y. The human secretome atlas initiative: implications in health and disease conditions. Biochim Biophys Acta. 2013 Nov; 1834(11):2454-61. PMID: 23603790; PMCID: PMC3755092.
    23. Duguez S, Duddy W, Johnston H, Lainé J, Le Bihan MC, Brown KJ, Bigot A, Hathout Y, Butler-Browne G, Partridge T. Dystrophin deficiency leads to disturbance of LAMP1-vesicle-associated protein secretion. Cell Mol Life Sci. 2013 Jun; 70(12):2159-74. PMID: 23344255.
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    24. Brown KJ, Marathi R, Fiorillo AA, Ciccimaro EF, Sharma S, Rowlands DS, Rayavarapu S, Nagaraju K, Hoffman EP, Hathout Y. Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry. J Bioanal Biomed. 2012 Dec 18; Suppl 7. PMID: 23646235.
      View in: PubMed
    25. Chen HL, Seol H, Brown KJ, Gordish-Dressman H, Hill A, Gallo V, Packer R, Hathout Y. Secretome survey of human plexiform neurofibroma derived Schwann Cells reveals a secreted form of the RARRES1 protein. Int J Mol Sci. 2012; 13(7):9380-99. PMID: 22942771; PMCID: PMC3430302.
    26. Sharma N, Medikayala S, Defour A, Rayavarapu S, Brown KJ, Hathout Y, Jaiswal JK. Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles. J Biol Chem. 2012 Aug 31; 287(36):30455-67. PMID: 22778268; PMCID: PMC3436295.
    27. Brown KJ, Formolo CA, Seol H, Marathi RL, Duguez S, An E, Pillai D, Nazarian J, Rood BR, Hathout Y. Advances in the proteomic investigation of the cell secretome. Expert Rev Proteomics. 2012 Jun; 9(3):337-45. PMID: 22809211; PMCID: PMC3500636.
    28. Brown KJ, Vanderver A, Hoffman EP, Schiffmann R, Hathout Y. Characterization of Transferrin Glycopeptide Structures in Human Cerebrospinal Fluid. Int J Mass Spectrom. 2012 Feb 15; 312:97-106. PMID: 22408387.
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    29. Zhang A, Williamson CD, Wong DS, Bullough MD, Brown KJ, Hathout Y, Colberg-Poley AM. Quantitative proteomic analyses of human cytomegalovirus-induced restructuring of endoplasmic reticulum-mitochondrial contacts at late times of infection. Mol Cell Proteomics. 2011 Oct; 10(10):M111.009936. PMID: 21742798; PMCID: PMC3205871.
    30. Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H. SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PLoS One. 2011; 6(6):e20216. PMID: 21687703; PMCID: PMC3110579.
    31. Formolo CA, Williams R, Gordish-Dressman H, MacDonald TJ, Lee NH, Hathout Y. Secretome signature of invasive glioblastoma multiforme. J Proteome Res. 2011 Jul 01; 10(7):3149-59. PMID: 21574646; PMCID: PMC3136381.
    32. Nazarian J, Berry DL, Sanjari S, Razvi M, Brown K, Hathout Y, Vertes A, Dadgar S, Hoffman EP. Evolution and comparative genomics of subcellular specializations: EST sequencing of Torpedo electric organ. Mar Genomics. 2011 Mar; 4(1):33-40. PMID: 21429463; PMCID: PMC3412124.
    33. Rajagopal MU, Hathout Y, MacDonald TJ, Kieran MW, Gururangan S, Blaney SM, Phillips P, Packer R, Gordish-Dressman H, Rood BR. Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study. Proteomics. 2011 Mar; 11(5):935-43. PMID: 21271676; PMCID: PMC3088509.
    34. Formolo CA, Mintz M, Takanohashi A, Brown KJ, Vanderver A, Halligan B, Hathout Y. Time series proteome profiling. Methods Mol Biol. 2011; 694:365-77. PMID: 21082445; PMCID: PMC4151876.
    35. Preciado D, Goyal S, Rahimi M, Watson AM, Brown KJ, Hathout Y, Rose MC. MUC5B Is the predominant mucin glycoprotein in chronic otitis media fluid. Pediatr Res. 2010 Sep; 68(3):231-6. PMID: 20531251; PMCID: PMC3679171.
    36. Shrestha B, Nemes P, Nazarian J, Hathout Y, Hoffman EP, Vertes A. Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry. Analyst. 2010 Apr; 135(4):751-8. PMID: 20349540.
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    37. An E, Sen S, Park SK, Gordish-Dressman H, Hathout Y. Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3379-86. PMID: 20207970; PMCID: PMC2904004.
    38. Reeves EK, Gordish-Dressman H, Hoffman EP, Hathout Y. Proteomic profiling of glucocorticoid-exposed myogenic cells: Time series assessment of protein translocation and transcription of inactive mRNAs. Proteome Sci. 2009 Jul 30; 7:26. PMID: 19642986; PMCID: PMC2725035.
    39. Jeong J, Rao AU, Xu J, Ogg SL, Hathout Y, Fenselau C, Mather IH. The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues. J Biol Chem. 2009 Aug 14; 284(33):22444-56. PMID: 19531472; PMCID: PMC2755966.
    40. Soler-García AA, Johnson D, Hathout Y, Ray PE. Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases. Clin J Am Soc Nephrol. 2009 Apr; 4(4):763-71. PMID: 19279121; PMCID: PMC2666435.
    41. An E, Gordish-Dressman H, Hathout Y. Effect of TNF-alpha on human ARPE-19-secreted proteins. Mol Vis. 2008; 14:2292-303. PMID: 19093006; PMCID: PMC2603184.
    42. Kantor L, Pinchasi D, Mintz M, Hathout Y, Vanderver A, Elroy-Stein O. A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells. PLoS One. 2008; 3(11):e3783. PMID: 19023445; PMCID: PMC2583043.
    43. Nazarian J, Santi M, Hathout Y, Macdonald TJ. Protein profiling of formalin fixed paraffin embedded tissue: Identification of potential biomarkers for pediatric brainstem glioma. Proteomics Clin Appl. 2008 Jun; 2(6):915-24. PMID: 21136889; PMCID: PMC3907167.
    44. Mintz M, Vanderver A, Brown KJ, Lin J, Wang Z, Kaneski C, Schiffmann R, Nagaraju K, Hoffman EP, Hathout Y. Time series proteome profiling to study endoplasmic reticulum stress response. J Proteome Res. 2008 Jun; 7(6):2435-44. PMID: 18435558; PMCID: PMC4154506.
    45. Lee B, Brown K, Hathout Y, Seo J. GOTreePlus: an interactive gene ontology browser. Bioinformatics. 2008 Apr 01; 24(7):1026-8. PMID: 18292113.
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    46. Befekadu GK, Tadesse MG, Hathout Y, Ressom HW. Multi-class alignment of LC-MS data using probabilistic-based mixture regression models. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:4094-7. PMID: 19163612; PMCID: PMC2714738.
    47. Shevchuk NA, Hathout Y, Epifano O, Su Y, Liu Y, Sutherland M, Ladisch S. Alteration of ganglioside synthesis by GM3 synthase knockout in murine embryonic fibroblasts. Biochim Biophys Acta. 2007 Sep; 1771(9):1226-34. PMID: 17604219.
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    48. Hathout Y. Approaches to the study of the cell secretome. Expert Rev Proteomics. 2007 Apr; 4(2):239-48. PMID: 17425459.
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    49. Nazarian J, Hathout Y, Vertes A, Hoffman EP. The proteome survey of an electricity-generating organ (Torpedo californica electric organ). Proteomics. 2007 Feb; 7(4):617-627. PMID: 17309107.
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    50. Hittel DS, Hathout Y, Hoffman EP. Proteomics and systems biology in exercise and sport sciences research. Exerc Sport Sci Rev. 2007 Jan; 35(1):5-11. PMID: 17211187.
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    51. Shi D, Caldovic L, Jin Z, Yu X, Qu Q, Roth L, Morizono H, Hathout Y, Allewell NM, Tuchman M. Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 01; 62(Pt 12):1218-22. PMID: 17142901; PMCID: PMC2225375.
    52. An E, Lu X, Flippin J, Devaney JM, Halligan B, Hoffman EP, Hoffman E, Strunnikova N, Csaky K, Hathout Y. Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors. J Proteome Res. 2006 Oct; 5(10):2599-610. PMID: 17022631.
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    53. Molon A, Di Giovanni S, Hathout Y, Natale J, Hoffman EP. Functional recovery of glycine receptors in spastic murine model of startle disease. Neurobiol Dis. 2006 Feb; 21(2):291-304. PMID: 16182553.
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    54. Vanderver A, Schiffmann R, Timmons M, Kellersberger KA, Fabris D, Hoffman EP, Maletkovic J, Hathout Y. Decreased asialotransferrin in cerebrospinal fluid of patients with childhood-onset ataxia and central nervous system hypomyelination/vanishing white matter disease. Clin Chem. 2005 Nov; 51(11):2031-42. PMID: 16155092.
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    55. Shi D, Yu X, Roth L, Morizono H, Hathout Y, Allewell NM, Tuchman M. Expression, purification, crystallization and preliminary X-ray crystallographic studies of a novel acetylcitrulline deacetylase from Xanthomonas campestris. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 01; 61(Pt 7):676-9. PMID: 16511126; PMCID: PMC1952451.
    56. Hittel DS, Hathout Y, Hoffman EP, Houmard JA. Proteome analysis of skeletal muscle from obese and morbidly obese women. Diabetes. 2005 May; 54(5):1283-8. PMID: 15855311.
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    57. Hathout Y, Flippin J, Fan C, Liu P, Csaky K. Metabolic labeling of human primary retinal pigment epithelial cells for accurate comparative proteomics. J Proteome Res. 2005 Mar-Apr; 4(2):620-7. PMID: 15822943.
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    58. Whiteaker JR, Warscheid B, Pribil P, Hathout Y, Fenselau C. Complete sequences of small acid-soluble proteins from Bacillus globigii. J Mass Spectrom. 2004 Oct; 39(10):1113-21. PMID: 15468161.
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    59. Gehrmann ML, Hathout Y, Fenselau C. Evaluation of metabolic labeling for comparative proteomics in breast cancer cells. J Proteome Res. 2004 Sep-Oct; 3(5):1063-8. PMID: 15473696.
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    60. Hathout Y, Gehrmann ML, Chertov A, Fenselau C. Proteomic phenotyping: metastatic and invasive breast cancer. Cancer Lett. 2004 Jul 16; 210(2):245-53. PMID: 15183541.
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    61. Gehrmann ML, Fenselau C, Hathout Y. Highly altered protein expression profile in the adriamycin resistant MCF-7 cell line. J Proteome Res. 2004 May-Jun; 3(3):403-9. PMID: 15253420.
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    62. Hathout Y, Setlow B, Cabrera-Martinez RM, Fenselau C, Setlow P. Small, acid-soluble proteins as biomarkers in mass spectrometry analysis of Bacillus spores. Appl Environ Microbiol. 2003 Feb; 69(2):1100-7. PMID: 12571035; PMCID: PMC143666.
    63. Hathout Y, Riordan K, Gehrmann M, Fenselau C. Differential protein expression in the cytosol fraction of an MCF-7 breast cancer cell line selected for resistance toward melphalan. J Proteome Res. 2002 Sep-Oct; 1(5):435-42. PMID: 12645915.
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    64. Afonso C, Hathout Y, Fenselau C. Qualitative characterization of biomolecular zinc complexes by collisionally induced dissociation. J Mass Spectrom. 2002 Jul; 37(7):755-9. PMID: 12125008.
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    65. Williams BH, Hathout Y, Fenselau C. Structural characterization of lipopeptide biomarkers isolated from Bacillus globigii. J Mass Spectrom. 2002 Mar; 37(3):259-64. PMID: 11921366.
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    66. Hathout Y, Reynolds KJ, Szilagyi Z, Fenselau C. Metallothionein dimers studied by nano-spray mass spectrometry. J Inorg Biochem. 2002 Jan 15; 88(2):119-22. PMID: 11803032.
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