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Van Den Anker, John

TitleExecutive Director, PPRU
InstitutionChildrens National Medical Center
DepartmentResearch CRI
Address111 Michigan Ave NW
Washington DC 20010
Phone(202) 476-2893
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mian P, Tibboel D, Wildschut ED, van den Anker JN, Allegaert K. Morphine treatment for Neonatal Abstinence Syndrome: huge dosing variability underscores the need for a better clinical study design. Minerva Pediatr. 2017 Mar 03. PMID: 28260350.
      View in: PubMed
    2. Pokorná P, Hronová K, Šíma M, Slanar O, Klement P, van den Anker JN, Tibboel D. Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report. Eur J Clin Pharmacol. 2017 Feb 06. PMID: 28168312.
      View in: PubMed
    3. Allegaert K, Lahav A, van den Anker JN. Erratum to: A Mechanism to Explain Ototoxicity in Neonates Exposed to Bumetanide: Lessons to Help Improve Future Product Development in Neonates. Paediatr Drugs. 2016 Dec; 18(6):475. PMID: 27665286.
      View in: PubMed
    4. Baarslag MA, Allegaert K, Van Den Anker JN, Knibbe CA, Van Dijk M, Simons SH, Tibboel D. Paracetamol and morphine for infant and neonatal pain; still a long way to go? Expert Rev Clin Pharmacol. 2017 Jan; 10(1):111-126. PMID: 27785937.
      View in: PubMed
    5. van den Anker JN, Allegaert K. Harmonized Use of Frequently Prescribed Medicines in Preterm Neonates: Mission Impossible? J Pediatr. 2017 Jan; 180:13-14. PMID: 27823766.
      View in: PubMed
    6. Cook SF, Stockmann C, Samiee-Zafarghandy S, King AD, Deutsch N, Williams EF, Wilkins DG, Sherwin CM, van den Anker JN. Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent-Metabolite Population Pharmacokinetic Model. Clin Pharmacokinet. 2016 Nov; 55(11):1395-1411. PMID: 27209292.
      View in: PubMed
    7. Meesters N, Simons S, van Rosmalen J, Reiss I, van den Anker J, van Dijk M. Waiting 2 minutes after sucrose administration-unnecessary? Arch Dis Child Fetal Neonatal Ed. 2017 Mar; 102(2):F167-F169. PMID: 28157669.
      View in: PubMed
    8. Allegaert K, Lahav A, van den Anker JN. A Mechanism to Explain Ototoxicity in Neonates Exposed to Bumetamide: Lessons to Help Improve Future Product Development in Neonates. Paediatr Drugs. 2016 Oct; 18(5):331-3. PMID: 27538744.
      View in: PubMed
    9. Vermeulen E, van den Anker JN, Della Pasqua O, Hoppu K, van der Lee JH. How to optimise drug study design: pharmacokinetics and pharmacodynamics studies introduced to paediatricians. J Pharm Pharmacol. 2017 Apr; 69(4):439-447. PMID: 27671925.
      View in: PubMed
    10. Smits A, Kulo A, van den Anker J, Allegaert K. The amikacin research program: a stepwise approach to validate dosing regimens in neonates. Expert Opin Drug Metab Toxicol. 2017 Feb; 13(2):157-166. PMID: 27623706.
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    11. Jancic J, Nikolic B, Ivancevic N, Djuric V, Zaletel I, Stevanovic D, Peric S, van den Anker JN, Samardzic J. Multiple Sclerosis in Pediatrics: Current Concepts and Treatment Options. Neurol Ther. 2016 Dec; 5(2):131-143. PMID: 27640189.
      View in: PubMed
    12. Samardzic J, Smits A, Spriet I, Soldatovic I, Atkinson A, Bajcetic M, Van Den Anker JN, Allegaert K. Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates. Biomed Res Int. 2016; 2016:1974972. PMID: 27635396; PMCID: PMC5011197.
    13. Hathout Y, Conklin LS, Seol H, Gordish-Dressman H, Brown KJ, Morgenroth LP, Nagaraju K, Heier CR, Damsker JM, van den Anker JN, Henricson E, Clemens PR, Mah JK, McDonald C, Hoffman EP. Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children. Sci Rep. 2016 Aug 17; 6:31727. PMID: 27530235; PMCID: PMC4987691.
    14. van den Anker JN, Allegaert K. Acetaminophen to Prevent Symptomatic Patent Ductus Arteriosus: Another Drug Bites the Dust? J Pediatr. 2016 Oct; 177:7-9. PMID: 27448839.
      View in: PubMed
    15. Allegaert K, van den Anker JN. Neonatal pain management: still in search for the Holy Grail. Int J Clin Pharmacol Ther. 2016 Jul; 54(7):514-23. PMID: 27087155; PMCID: PMC5012190.
    16. Smits A, van den Anker JN, Allegaert K. Clinical pharmacology of analgosedatives in neonates: ways to improve their safe and effective use. J Pharm Pharmacol. 2017 Apr; 69(4):350-360. PMID: 27364566.
      View in: PubMed
    17. Ritz N, Bielicki J, Pfister M, van den Anker J. Therapeutic Drug Monitoring for Anti-infective Agents in Pediatrics: The Way Forward. Pediatr Infect Dis J. 2016 May; 35(5):570-2. PMID: 26862676.
      View in: PubMed
    18. Shoji K, Bradley JS, Reed MD, van den Anker JN, Domonoske C, Capparelli EV. Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms. Antimicrob Agents Chemother. 2016 Apr; 60(4):2150-6. PMID: 26810655; PMCID: PMC4808231 [Available on 10/01/16].
    19. Samardzic J, Allegaert K, Wilbaux M, Pfister M, van den Anker JN. Quantitative clinical pharmacology practice for optimal use of antibiotics during the neonatal period. Expert Opin Drug Metab Toxicol. 2016; 12(4):367-75. PMID: 26817821.
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    20. van den Anker JN, Allegaert K. Evidence-Based Use of a-2 Agonists for Sedation in the PICU: From Fiction to Facts? Pediatr Crit Care Med. 2016 Feb; 17(2):182-3. PMID: 26841036.
      View in: PubMed
    21. Jancic J, Duric V, Ivancevic N, Nikolic B, van den Anker JN, Samardzic J. Current Use of mTOR Inhibitors for the Treatment of Subependymal Giant Cell Astrocytomas and Epilepsy in Patients with TSC. Curr Med Chem. 2016; 23(37):4260-4269. PMID: 27739368.
      View in: PubMed
    22. Cook SF, Roberts JK, Samiee-Zafarghandy S, Stockmann C, King AD, Deutsch N, Williams EF, Allegaert K, Wilkins DG, Sherwin CM, van den Anker JN. Population Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) in Preterm and Term Neonates: Model Development and External Evaluation. Clin Pharmacokinet. 2016 Jan; 55(1):107-19. PMID: 26201306.
      View in: PubMed
    23. Vila MC, Klimek MB, Novak JS, Rayavarapu S, Uaesoontrachoon K, Boehler JF, Fiorillo AA, Hogarth MW, Zhang A, Shaughnessy C, Gordish-Dressman H, Burki U, Straub V, Lu QL, Partridge TA, Brown KJ, Hathout Y, van den Anker J, Hoffman EP, Nagaraju K. Elusive sources of variability of dystrophin rescue by exon skipping. Skelet Muscle. 2015; 5:44. PMID: 26634117; PMCID: PMC4667482.
    24. van den Anker JN. How to Improve the Safe and Effective Use of Doxorubicin in Children with Cancer. Clin Pharmacokinet. 2015 Nov; 54(11):1091-3. PMID: 26123706.
      View in: PubMed
    25. Cook SF, King AD, van den Anker JN, Wilkins DG. Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Method validation and application to a neonatal pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15; 1007:30-42. PMID: 26571452.
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    26. Allegaert K, van den Anker JN. Neonatal withdrawal syndrome: reaching epidemic proportions across the globe. Arch Dis Child Fetal Neonatal Ed. 2016 Jan; 101(1):F2-3. PMID: 26482412.
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    27. van den Anker JN, Allegaert K. Treating Pain in Preterm Infants: Moving from Opioids to Acetaminophen. J Pediatr. 2016 Jan; 168:13-5. PMID: 26490127.
      View in: PubMed
    28. Mushtaq A, Vaughns JD, Ziesenitz VC, Nadler EP, van den Anker JN. Use of Enoxaparin in Obese Adolescents During Bariatric Surgery--a Pilot Study. Obes Surg. 2015 Oct; 25(10):1869-74. PMID: 25716128.
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    29. Marra EM, Mazer-Amirshahi M, Brooks G, van den Anker J, May L, Pines JM. Benzodiazepine Prescribing in Older Adults in U.S. Ambulatory Clinics and Emergency Departments (2001-10). J Am Geriatr Soc. 2015 Oct; 63(10):2074-81. PMID: 26415836.
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    30. Jacqz-Aigrain E, Leroux S, Zhao W, van den Anker JN, Sharland M. How to use vancomycin optimally in neonates: remaining questions. Expert Rev Clin Pharmacol. 2015; 8(5):635-48. PMID: 26289222.
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    31. Roofthooft DW, van Beynum IM, de Klerk JC, van Dijk M, van den Anker JN, Reiss IK, Tibboel D, Simons SH. Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. Eur J Pediatr. 2015 Nov; 174(11):1433-40. PMID: 25922139; PMCID: PMC4623081.
    32. Valitalo PA, van den Anker JN, Allegaert K, de Cock RF, de Hoog M, Simons SH, Mouton JW, Knibbe CA. Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates. J Antimicrob Chemother. 2015 Jul; 70(7):2074-7. PMID: 25766737; PMCID: PMC4472325.
    33. Pokorna P, Wildschut ED, Vobruba V, van den Anker JN, Tibboel D. The Impact of Hypothermia on the Pharmacokinetics of Drugs Used in Neonates and Young Infants. Curr Pharm Des. 2015; 21(39):5705-24. PMID: 26323408.
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    34. Allegaert K, Cossey V, van den Anker JN. Dosing Guidelines of Aminoglycosides in Neonates: A Balance Between Physiology and Feasibility. Curr Pharm Des. 2015; 21(39):5699-704. PMID: 26323409.
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    35. Allegaert K, Cosaert K, van den Anker JN. Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach. Curr Pharm Des. 2015; 21(39):5674-9. PMID: 26323412.
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    36. Bajcetic M, Kearns GL, Jovanovic I, Brajovic M, van den Anker JN. Availability of Oral Formulations Labeled for Use in Young Children in Serbia, Germany and the USA. Curr Pharm Des. 2015; 21(39):5668-73. PMID: 26323413.
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    37. Vaughns JD, Ziesenitz VC, van den Anker JN. Clinical Pharmacology of Frequently Used Intravenous Drugs During Bariatric Surgery in Adolescents. Curr Pharm Des. 2015; 21(39):5650-9. PMID: 26323414.
      View in: PubMed
    38. van den Anker JN. Editorial: Neonatal and Pediatric Clinical Pharmacology. Curr Pharm Des. 2015; 21(39):5617-8. PMID: 26607635.
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    39. Zhang A, Uaesoontrachoon K, Shaughnessy C, Das JR, Rayavarapu S, Brown KJ, Ray PE, Nagaraju K, van den Anker JN, Hoffman EP, Hathout Y. The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse. Toxicol Rep. 2015; 2:838-849. PMID: 26213685.
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    40. Samiee-Zafarghandy S, Raman SR, van den Anker JN, McHutchison K, Hornik CP, Clark RH, Brian Smith P. Safety of milrinone use in neonatal intensive care units. Early Hum Dev. 2015 Jan; 91(1):31-5. PMID: 25460254; PMCID: PMC4302030.
    41. van den Anker JN, Allegaert K, Kraft WK. Current Therapeutic Research is Now Indexed on PubMed. Curr Ther Res Clin Exp. 2014 Dec; 76:98. PMID: 25389447; PMCID: PMC4226836.
    42. Allegaert K, Mekahli D, van den Anker J. Cystatin C in newborns: a promising renal biomarker in search for standardization and validation. J Matern Fetal Neonatal Med. 2015; 28(15):1833-8. PMID: 25260126; PMCID: PMC4757591.
    43. Allegaert K, van den Anker JN. The addition of tramadol to a standard i.v. acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy? Paediatr Anaesth. 2014 Nov; 24(11):1189-90. PMID: 25279676; PMCID: PMC4185408.
    44. Pansieri C, Pandolfini C, Jacqz-Aigrain E, van den Anker J, Bonati M. Fluconazole prophylaxis in neonates. Arch Dis Child. 2015 Jan; 100(1):75-6. PMID: 25341552.
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    45. Mazer-Amirshahi M, Rasooly I, Brooks G, Pines J, May L, van den Anker J. The impact of pediatric labeling changes on prescribing patterns of cough and cold medications. J Pediatr. 2014 Nov; 165(5):1024-8.e1. PMID: 25195159.
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    46. Mazer-Amirshahi M, Mullins PM, Rasooly I, van den Anker J, Pines JM. In reply. Acad Emerg Med. 2014 Aug; 21(8):947. PMID: 25154412.
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    47. Mazer-Amirshahi M, Dewey K, Mullins PM, van den Anker J, Pines JM, Perrone J, Nelson L. Trends in opioid analgesic use for headaches in US emergency departments. Am J Emerg Med. 2014 Sep; 32(9):1068-73. PMID: 25091873.
      View in: PubMed
    48. Allegaert K, van den Anker JN. Neonatal abstinence syndrome: on the evidence to add breastfeeding to any clinical pathway. Pediatr Crit Care Med. 2014 Jul; 15(6):579-80. PMID: 25000433; PMCID: PMC4122260.
    49. Rasooly IR, Mullins PM, Mazer-Amirshahi M, van den Anker J, Pines JM. The impact of race on analgesia use among pediatric emergency department patients. J Pediatr. 2014 Sep; 165(3):618-21. PMID: 24928697.
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    50. Mazer-Amirshahi M, Pourmand A, Singer S, Pines JM, van den Anker J. Critical drug shortages: implications for emergency medicine. Acad Emerg Med. 2014 Jun; 21(6):704-11. PMID: 25039558.
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    51. Allegaert K, Pauwels S, Smits A, Crèvecoeur K, van den Anker J, Mekahli D, Vermeersch P. Enzymatic isotope dilution mass spectrometry (IDMS) traceable serum creatinine is preferable over Jaffe in neonates and young infants. Clin Chem Lab Med. 2014 Jun; 52(6):e107-9. PMID: 24399679.
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    52. Allegaert K, van den Anker JN. Clinical pharmacology in neonates: small size, huge variability. Neonatology. 2014; 105(4):344-9. PMID: 24931327; PMCID: PMC4111147.
    53. van den Anker JN. The impact of therapeutic drug monitoring in neonatal clinical pharmacology. Clin Biochem. 2014 Jun; 47(9):704-5. PMID: 24854683.
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    54. Mazer-Amirshahi M, van den Anker J. Best pharmaceuticals for children: how far have we come? Curr Ther Res Clin Exp. 2014 Dec; 76:32-3. PMID: 25067983; PMCID: PMC4008771.
    55. Mazer-Amirshahi M, Mullins PM, Rasooly IR, van den Anker J, Pines JM. Trends in prescription opioid use in pediatric emergency department patients. Pediatr Emerg Care. 2014 Apr; 30(4):230-5. PMID: 24651218.
      View in: PubMed
    56. Mazer-Amirshahi M, Mullins PM, van den Anker J, Meltzer A, Pines JM. Rising rates of proton pump inhibitor prescribing in US emergency departments. Am J Emerg Med. 2014 Jun; 32(6):618-22. PMID: 24721025.
      View in: PubMed
    57. van den Anker JN. How to optimize the evaluation and use of antibiotics in neonates. Early Hum Dev. 2014 Mar; 90 Suppl 1:S10-2. PMID: 24709446.
      View in: PubMed
    58. Mazer-Amirshahi M, Mullins PM, Rasooly I, van den Anker J, Pines JM. Rising opioid prescribing in adult U.S. emergency department visits: 2001-2010. Acad Emerg Med. 2014 Mar; 21(3):236-43. PMID: 24628748.
      View in: PubMed
    59. Anderson BJ, van den Anker J. Why is there no morphine concentration-response curve for acute pain? Paediatr Anaesth. 2014 Mar; 24(3):233-8. PMID: 24467568.
      View in: PubMed
    60. Frattarelli DA, Galinkin JL, Green TP, Johnson TD, Neville KA, Paul IM, Van Den Anker JN. Off-label use of drugs in children. Pediatrics. 2014 Mar; 133(3):563-7. PMID: 24567009.
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    61. Bhattacharyya S, Yan K, Pence L, Simpson PM, Gill P, Letzig LG, Beger RD, Sullivan JE, Kearns GL, Reed MD, Marshall JD, Van Den Anker JN, James LP. Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children. Biomark Med. 2014; 8(2):147-59. PMID: 24521011; PMCID: PMC4125006.
    62. Ziesenitz VC, van den Anker JN. Impact of CYP3A and ABCB1 polymorphisms on the pharmacokinetics and pharmacodynamics of fentanyl. Int J Clin Pharmacol Ther. 2013 Dec; 51(12):991-2. PMID: 24161162.
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    63. Samiee S, van den Anker J. Is there really a need to adjust gentamicin dosing in neonates treated with hypothermia? Ther Drug Monit. 2013 Dec; 35(6):872. PMID: 24263645.
      View in: PubMed
    64. Fjalstad JW, Laukli E, van den Anker JN, Klingenberg C. High-dose gentamicin in newborn infants: is it safe? Eur J Pediatr. 2013 Nov 14. PMID: 24233331.
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    65. Samiee-Zafarghandy S, van den Anker JN. Do we really need continuous vancomycin infusion in neonates? Arch Dis Child. 2013 Dec; 98(12):1023-4. PMID: 23928649.
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    66. Pearl PL, McCarter R, McGavin CL, Yu Y, Sandoval F, Trzcinski S, Atabaki SM, Tsuchida T, van den Anker J, He J, Klein P. Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy. Epilepsia. 2013 Sep; 54(9):e135-7. PMID: 23876024; PMCID: PMC3769484.
    67. Reid N, Mazer-Amirshahi M, Clancy C, James L, van den Anker J. Elevated acetaminophen concentration measured after nasal insufflation of Percocet®. J Emerg Med. 2013 Nov; 45(5):683-5. PMID: 23880443.
      View in: PubMed
    68. Mazer-Amirshahi M, van den Anker J. Is paracetamol safe and effective for ductus arteriosus closure? Arch Dis Child. 2013 Oct; 98(10):831. PMID: 23864357.
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    69. Hornik CP, Herring AH, Benjamin DK, Capparelli EV, Kearns GL, van den Anker J, Cohen-Wolkowiez M, Clark RH, Smith PB. Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants. Pediatr Infect Dis J. 2013 Jul; 32(7):748-53. PMID: 23838776; PMCID: PMC3708263.
    70. Kaguelidou F, Turner MA, Choonara I, van den Anker J, van Anker J, Manzoni P, Alberti C, Langhendries JP, Jacqz-Aigrain E. Randomized controlled trials of antibiotics for neonatal infections: a systematic review. Br J Clin Pharmacol. 2013 Jul; 76(1):21-9. PMID: 23488627; PMCID: PMC3703225.
    71. Ince I, de Wildt SN, Wang C, Wang C, Peeters MY, Burggraaf J, Jacqz-Aigrain E, van den Anker JN, Tibboel D, Danhof M, Knibbe CA. A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults. Clin Pharmacokinet. 2013 Jul; 52(7):555-65. PMID: 23512668.
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    72. Mazer-Amirshahi M, Reid N, van den Anker J, Litovitz T. Effect of cough and cold medication restriction and label changes on pediatric ingestions reported to United States poison centers. J Pediatr. 2013 Nov; 163(5):1372-6. PMID: 23769500.
      View in: PubMed
    73. Drake R, Anderson BJ, van den Anker JN, Zernikow B. Managing persisting pain in children with medical illnesses: another frontier unexplored. Paediatr Anaesth. 2013 May; 23(5):381-4. PMID: 23577820.
      View in: PubMed
    74. Allegaert K, van de Velde M, van den Anker J. Neonatal clinical pharmacology. Paediatr Anaesth. 2014 Jan; 24(1):30-8. PMID: 23617305; PMCID: PMC3758438.
    75. Zhao W, Kaguelidou F, Biran V, Zhang D, Allegaert K, Capparelli EV, Holford N, Kimura T, Lo YL, Peris JE, Thomson A, van den Anker JN, Fakhoury M, Jacqz-Aigrain E. External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings. Br J Clin Pharmacol. 2013 Apr; 75(4):1068-80. PMID: 23148919; PMCID: PMC3612725.
    76. Mazer-Amirshahi M, van den Anker J. Impact of the CYP2C19*17 polymorphism on the pharmacokinetics and pharmacodynamics of proton pump inhibitors. J Clin Pharmacol. 2013 Mar; 53(3):359. PMID: 23381740.
      View in: PubMed
    77. Du W, Lehr VT, Lieh-Lai M, Koo W, Ward RM, Rieder MJ, Van Den Anker JN, Reeves JH, Mathew M, Lulic-Botica M, Aranda JV. An algorithm to detect adverse drug reactions in the neonatal intensive care unit. J Clin Pharmacol. 2013 Jan; 53(1):87-95. PMID: 23400748.
      View in: PubMed
    78. Mazer-Amirshahi M, Sokol G, van den Anker J, Cantilena L. A review of pharmaceutical labeling for overdose treatment and toxicity data. Pharmacoepidemiol Drug Saf. 2013 Mar; 22(3):319-23. PMID: 23283832.
      View in: PubMed
    79. van den Anker JN. Optimising the management of fever and pain in children. Int J Clin Pract Suppl. 2013 Jan; (178):26-32. PMID: 23163545.
      View in: PubMed
    80. Allegaert K, Thewissen L, van den Anker JN. Remifentanil in neonates: a promising compound in search of its indications? Pediatr Neonatol. 2012 Dec; 53(6):387-8. PMID: 23276446.
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    81. van den Anker J, Allegaert K. Perinatal pharmacology. Semin Fetal Neonatal Med. 2013 Feb; 18(1):1-2. PMID: 23207019; PMCID: PMC4709251.
    82. Wildschut ED, de Wildt SN, Mâthot RA, Reiss IK, Tibboel D, Van den Anker J. Effect of hypothermia and extracorporeal life support on drug disposition in neonates. Semin Fetal Neonatal Med. 2013 Feb; 18(1):23-7. PMID: 23158109.
      View in: PubMed
    83. Jacqz-Aigrain E, Zhao W, Sharland M, van den Anker JN. Use of antibacterial agents in the neonate: 50 years of experience with vancomycin administration. Semin Fetal Neonatal Med. 2013 Feb; 18(1):28-34. PMID: 23137927.
      View in: PubMed
    84. Berlin CM, van den Anker JN. Safety during breastfeeding: drugs, foods, environmental chemicals, and maternal infections. Semin Fetal Neonatal Med. 2013 Feb; 18(1):13-8. PMID: 23131768.
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    85. Noel GJ, Van Den Anker JN, Lombardi D, Ward R. Improving drug formulations for neonates: making a big difference in our smallest patients. J Pediatr. 2012 Nov; 161(5):947-9. PMID: 23095694.
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    86. Allegaert K, Tibboel D, van den Anker J. Pharmacological treatment of neonatal pain: in search of a new equipoise. Semin Fetal Neonatal Med. 2013 Feb; 18(1):42-7. PMID: 23107602; PMCID: PMC4709244.
    87. Klein P, Herr D, Pearl PL, Natale J, Levine Z, Nogay C, Sandoval F, Trzcinski S, Atabaki SM, Tsuchida T, van den Anker J, Soldin SJ, He J, McCarter R. Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. Arch Neurol. 2012 Oct; 69(10):1290-5. PMID: 22777131; PMCID: PMC4798941.
    88. Cohen-Wolkowiez M, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Randolph DA, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Rich W, Brozanski BS, van den Anker J, Blumer J, Laughon M, Watt KM, Kearns GL, Capparelli EV, Martz K, Berezny K, Benjamin DK, Smith PB. Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. Clin Infect Dis. 2012 Dec; 55(11):1495-502. PMID: 22955430; PMCID: PMC3491861.
    89. Jacqz-Aigrain E, Kaguelidou F, van den Anker JN. How to optimize the evaluation and use of antibiotics in neonates. Pediatr Clin North Am. 2012 Oct; 59(5):1117-28. PMID: 23036247; PMCID: PMC4709255.
    90. Kraft WK, van den Anker JN. Pharmacologic management of the opioid neonatal abstinence syndrome. Pediatr Clin North Am. 2012 Oct; 59(5):1147-65. PMID: 23036249; PMCID: PMC4709246.
    91. Wildschut ED, van Saet A, Pokorna P, Ahsman MJ, Van den Anker JN, Tibboel D. The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children. Pediatr Clin North Am. 2012 Oct; 59(5):1183-204. PMID: 23036251; PMCID: PMC4709257.
    92. van den Anker JN, Coppes MJ, Koren G. Neonatal and pediatric clinical pharmacology. Pediatr Clin North Am. 2012 Oct; 59(5):xv-xviii. PMID: 23036253.
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    93. Allegaert K, van den Anker JN. Creatinine-based vancomycin dosing regimens in neonates: there is more to consider than the variation in drug assay. Pharmacotherapy. 2012 Sep; 32(9):e174; discussion e175. PMID: 22859254.
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    94. Klein P, Herr D, Pearl PL, Natale J, Levine Z, Nogay C, Sandoval F, Trzcinsky S, Atabaki SM, Tsuchida T, van den Anker J, Soldin SJ, He J, McCarter R. Results of phase II pharmacokinetic study of levetiracetam for prevention of post-traumatic epilepsy. Epilepsy Behav. 2012 Aug; 24(4):457-61. PMID: 22771222; PMCID: PMC4561854.
    95. Allegaert K, Langhendries JP, van den Anker JN. Educational paper: do we need neonatal clinical pharmacologists? Eur J Pediatr. 2013 Apr; 172(4):429-35. PMID: 22588521; PMCID: PMC4709249.
    96. Brill MJ, Diepstraten J, van Rongen A, van Kralingen S, van den Anker JN, Knibbe CA. Impact of obesity on drug metabolism and elimination in adults and children. Clin Pharmacokinet. 2012 May 01; 51(5):277-304. PMID: 22448619.
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    97. Kelly LE, Rieder M, van den Anker J, Malkin B, Ross C, Neely MN, Carleton B, Hayden MR, Madadi P, Koren G. More codeine fatalities after tonsillectomy in North American children. Pediatrics. 2012 May; 129(5):e1343-7. PMID: 22492761.
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    98. Allegaert K, Kuppens M, Mekahli D, Levtchenko E, Vanstapel F, Vanhole C, van den Anker JN. Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method. J Matern Fetal Neonatal Med. 2012 Sep; 25(9):1678-81. PMID: 22273037.
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    99. van den Anker J, Allegaert K. Clinical pharmacology in neonates and young infants: the benefit of a population-tailored approach. Expert Rev Clin Pharmacol. 2012 Jan; 5(1):5-8. PMID: 22142152; PMCID: PMC4709247.
    100. Best BM, Capparelli EV, Diep H, Rossi SS, Farrell MJ, Williams E, Lee G, van den Anker JN, Rakhmanina N. Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children. J Acquir Immune Defic Syndr. 2011 Dec 01; 58(4):385-91. PMID: 21876444; PMCID: PMC3205189.
    101. Chamberlain JM, Capparelli EV, Brown KM, Vance CW, Lillis K, Mahajan P, Lichenstein R, Stanley RM, Davis CO, Gordon S, Baren JM, van den Anker JN. Pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus. J Pediatr. 2012 Apr; 160(4):667-672.e2. PMID: 22050870; PMCID: PMC3274567.
    102. Allegaert K, van den Anker J. Pharmacokinetics and pharmacodynamics of intravenous acetaminophen in neonates. Expert Rev Clin Pharmacol. 2011 Nov; 4(6):713-8. PMID: 22111857.
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    103. van den Anker JN. Is it safe to use opioids for obstetric pain while breastfeeding? J Pediatr. 2012 Jan; 160(1):4-6. PMID: 21996159.
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    104. Smith PB, Cohen-Wolkowiez M, Castro LM, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Bhatt-Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Brozanski BS, Sanchez P, van den Anker J, Blumer J, Kearns GL, Capparelli EV, Anand R, Benjamin DK. Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatr Infect Dis J. 2011 Oct; 30(10):844-9. PMID: 21829139; PMCID: PMC3173561.
    105. Rakhmanina NY, Neely MN, Van Schaik RH, Gordish-Dressman HA, Williams KD, Soldin SJ, van den Anker JN. CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children. Ther Drug Monit. 2011 Aug; 33(4):417-24. PMID: 21743379; PMCID: PMC3139013.
    106. van den Berg H, van den Anker JN, Beijnen JH. Cytostatic drugs in infants: a review on pharmacokinetic data in infants. Cancer Treat Rev. 2012 Feb; 38(1):3-26. PMID: 21489698.
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    107. van den Anker JN. Getting the dose of vancomycin right in the neonate. Int J Clin Pharmacol Ther. 2011 Apr; 49(4):247-9. PMID: 21429437.
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    108. van den Anker JN, Tibboel D. Pain relief in neonates: when to use intravenous paracetamol. Arch Dis Child. 2011 Jun; 96(6):573-4. PMID: 21441241.
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    109. van den Anker JN. Sodium alginate in preterm infants: game, set, and match? J Clin Pharmacol. 2012 Mar; 52(3):446; author reply 447. PMID: 21383340.
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    110. van den Anker J. Developing an assay for ceftazidime: is it worth the effort? Ther Drug Monit. 2011 Feb; 33(1):132. PMID: 21233691.
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    111. Darbari DS, Neely M, van den Anker J, Rana S. Increased clearance of morphine in sickle cell disease: implications for pain management. J Pain. 2011 May; 12(5):531-8. PMID: 21277838; PMCID: PMC3086992.
    112. Rakhmanina NY, van den Anker JN, Soldin SJ, van Schaik RH, Mordwinkin N, Neely MN. Can therapeutic drug monitoring improve pharmacotherapy of HIV infection in adolescents? Ther Drug Monit. 2010 Jun; 32(3):273-81. PMID: 20445485; PMCID: PMC2886015.
    113. Leeder JS, Kearns GL, Spielberg SP, van den Anker J. Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science. J Clin Pharmacol. 2010 Dec; 50(12):1377-87. PMID: 20150527.
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    114. Rakhmanina NY, van den Anker JN. Treating an HIV-infected paediatric patient: an easy task? Antivir Ther. 2010; 15(3):293-6. PMID: 20516549.
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    115. Robb AS, van den Anker JN. Introduction: psychopharmacology. Dev Disabil Res Rev. 2010; 16(3):231-2. PMID: 20981760.
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    116. Rakhmanina NY, van den Anker JN. Efavirenz in the therapy of HIV infection. Expert Opin Drug Metab Toxicol. 2010 Jan; 6(1):95-103. PMID: 20001610; PMCID: PMC2810555.
    117. de Wildt SN, Kearns GL, Murry DJ, Koren G, van den Anker JN. Ontogeny of midazolam glucuronidation in preterm infants. Eur J Clin Pharmacol. 2010 Feb; 66(2):165-70. PMID: 19838691; PMCID: PMC2805794.
    118. Connor E, Lombardi D, van den Anker J. More than baby steps: perspectives on pediatric translational research. Sci Transl Med. 2009 Oct 14; 1(2):2cm2. PMID: 20368160.
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    119. Allegaert K, Vanhaesebrouck S, Verbesselt R, van den Anker JN. In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age. Ther Drug Monit. 2009 Aug; 31(4):411-5. PMID: 19494793.
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    120. van den Anker JN, Allegaert K. Individualized dosing of aminoglycosides in neonates: mission accomplished or work in progress? Eur J Clin Pharmacol. 2009 Nov; 65(11):1159-60. PMID: 19582439; PMCID: PMC2764056.
    121. Bassler D, Halliday HL, Plavka R, Hallman M, Shinwell ES, Jarreau PH, Carnielli V, van den Anker J, Schwab M, Poets CF. The Neonatal European Study of Inhaled Steroids (NEUROSIS): an eu-funded international randomised controlled trial in preterm infants. Neonatology. 2010; 97(1):52-5. PMID: 19590247.
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    122. van den Anker JN, Pokorna P, Kinzig-Schippers M, Martinkova J, de Groot R, Drusano GL, Sorgel F. Meropenem pharmacokinetics in the newborn. Antimicrob Agents Chemother. 2009 Sep; 53(9):3871-9. PMID: 19581463; PMCID: PMC2737888.
    123. van den Anker J. Use of aminoglycosides in preterm neonates: a simple task? J Pediatr. 2009 Jun; 154(6):935. PMID: 19446105.
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    124. Rakhmanina N, van den Anker J, Baghdassarian A, Soldin S, Williams K, Neely MN. Population pharmacokinetics of lopinavir predict suboptimal therapeutic concentrations in treatment-experienced human immunodeficiency virus-infected children. Antimicrob Agents Chemother. 2009 Jun; 53(6):2532-8. PMID: 19258274; PMCID: PMC2687254.
    125. de Hoog M, van den Anker JN. Therapeutic drug monitoring of aminoglycosides in neonates. Clin Pharmacokinet. 2009; 48(5):343-4; author reply 344-5. PMID: 19566117.
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    126. Allegaert K, van Schaik RH, Vermeersch S, Verbesselt R, Cossey V, Vanhole C, van Fessem M, de Hoon J, van den Anker JN. Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Pediatr Res. 2008 Jun; 63(6):674-9. PMID: 18317231.
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    127. Darbari DS, Minniti CP, Rana S, van den Anker J. Pharmacogenetics of morphine: Potential implications in sickle cell disease. Am J Hematol. 2008 Mar; 83(3):233-6. PMID: 17722074.
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    128. Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J. UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol. 2008 Mar; 83(3):200-2. PMID: 17724700.
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    129. van den Anker JN. Timing of dose-finding studies: before or after completion of a randomized clinical trial? Pediatrics. 2007 Sep; 120(3):691-2; author reply 392-3. PMID: 17766549.
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    130. Krekels EH, van den Anker JN, Baiardi P, Cella M, Cheng KY, Gibb DM, Green H, Iolascon A, Jacqz-Aigrain EM, Knibbe CA, Santen GW, van Schaik RH, Tibboel D, Della Pasqua OE. Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations. Expert Opin Pharmacother. 2007 Aug; 8(12):1787-99. PMID: 17696784.
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    131. Muller AE, DeJongh J, Bult Y, Goessens WH, Mouton JW, Danhof M, van den Anker JN. Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. Antimicrob Agents Chemother. 2007 Oct; 51(10):3720-5. PMID: 17646418; PMCID: PMC2043294.
    132. van den Anker JN. Do we need to incorporate pharmacogenetics in randomized, controlled trials of frequently used medicines? Pediatrics. 2007 Jul; 120(1):237; author reply 237-8. PMID: 17606585.
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    133. Allegaert K, Anderson BJ, van den Anker JN, Vanhaesebrouck S, de Zegher F. Renal drug clearance in preterm neonates: relation to prenatal growth. Ther Drug Monit. 2007 Jun; 29(3):284-91. PMID: 17529884.
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    134. de Wildt SN, Verzijden R, van den Anker JN, de Hoog M. Information technology cannot guarantee patient safety. BMJ. 2007 Apr 21; 334(7598):851-2. PMID: 17446618; PMCID: PMC1853195.
    135. de Wildt SN, Berns MJ, van den Anker JN. 13C-erythromycin breath test as a noninvasive measure of CYP3A activity in newborn infants: a pilot study. Ther Drug Monit. 2007 Apr; 29(2):225-30. PMID: 17417078.
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    136. Rakhmanina NY, Capparelli EV, van den Anker JN, Williams K, Sever JL, Spiegel HM, Soldin SJ. Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infection. Ther Drug Monit. 2007 Feb; 29(1):110-7. PMID: 17304158.
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    137. van den Anker JN. Use of ibuprofen in paediatric populations. J R Soc Med. 2007; 100 Suppl 48:18-22. PMID: 18335850.
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    138. Allegaert K, van den Anker JN, Naulaers G, de Hoon J. Determinants of drug metabolism in early neonatal life. Curr Clin Pharmacol. 2007 Jan; 2(1):23-9. PMID: 18690852.
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    139. Heresi GP, Gerstmann DR, Reed MD, van den Anker JN, Blumer JL, Kovanda L, Keirns JJ, Buell DN, Kearns GL. The pharmacokinetics and safety of micafungin, a novel echinocandin, in premature infants. Pediatr Infect Dis J. 2006 Dec; 25(12):1110-5. PMID: 17133155.
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    140. van den Anker JN. Population pharmacokinetics and dosing of amoxicillin in (pre)term neonates. Ther Drug Monit. 2006 Dec; 28(6):816; author reply 816-7. PMID: 17164701.
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    141. Anderson BJ, Allegaert K, Van den Anker JN, Cossey V, Holford NH. Vancomycin pharmacokinetics in preterm neonates and the prediction of adult clearance. Br J Clin Pharmacol. 2007 Jan; 63(1):75-84. PMID: 16869817; PMCID: PMC2000709.
    142. Rakhmanina NY, van den Anker JN. Pharmacological research in pediatrics: From neonates to adolescents. Adv Drug Deliv Rev. 2006 Apr 20; 58(1):4-14. PMID: 16533543.
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    143. Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN. Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet. 2006; 45(11):1077-97. PMID: 17048973.
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    144. de Wildt SN, de Hoog M, Vinks AA, Joosten KF, van Dijk M, van den Anker JN. Pharmacodynamics of midazolam in pediatric intensive care patients. Ther Drug Monit. 2005 Feb; 27(1):98-102. PMID: 15665754.
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    145. van den Anker JN. Managing drugs safely. Semin Fetal Neonatal Med. 2005 Feb; 10(1):73-81. PMID: 15698972.
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    146. de Hoog M, Mouton JW, van den Anker JN. New dosing strategies for antibacterial agents in the neonate. Semin Fetal Neonatal Med. 2005 Apr; 10(2):185-94. PMID: 15701583.
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    147. Rakhmanina NY, van den Anker JN, Soldin SJ. Safety and pharmacokinetics of antiretroviral therapy during pregnancy. Ther Drug Monit. 2004 Apr; 26(2):110-5. PMID: 15228149.
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    148. Rakhmanina NY, van den Anker JN, Soldin SJ. Therapeutic drug monitoring of antiretroviral therapy. AIDS Patient Care STDS. 2004 Jan; 18(1):7-14. PMID: 15006189.
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    149. de Hoog M, Mouton JW, van den Anker JN. Vancomycin: pharmacokinetics and administration regimens in neonates. Clin Pharmacokinet. 2004; 43(7):417-40. PMID: 15139793.
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    150. Simons SH, van Dijk M, van Lingen RA, Roofthooft D, Duivenvoorden HJ, Jongeneel N, Bunkers C, Smink E, Anand KJ, van den Anker JN, Tibboel D. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA. 2003 Nov 12; 290(18):2419-27. PMID: 14612478.
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    151. Kearns GL, Jungbluth GL, Abdel-Rahman SM, Hopkins NK, Welshman IR, Grzebyk RP, Bruss JB, Van Den Anker JN. Impact of ontogeny on linezolid disposition in neonates and infants. Clin Pharmacol Ther. 2003 Nov; 74(5):413-22. PMID: 14586382.
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    152. Kearns GL, Robinson PK, Wilson JT, Wilson-Costello D, Knight GR, Ward RM, van den Anker JN. Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny. Clin Pharmacol Ther. 2003 Oct; 74(4):312-25. PMID: 14534518.
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    153. Kearns GL, Andersson T, James LP, Gaedigk A, Kraynak RA, Abdel-Rahman SM, Ramabadran K, van den Anker JN. Omeprazole disposition in children following single-dose administration. J Clin Pharmacol. 2003 Aug; 43(8):840-8. PMID: 12953341.
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    154. Bouwmeester NJ, Hop WC, van Dijk M, Anand KJ, van den Anker JN, Tibboel D. Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism. Intensive Care Med. 2003 Nov; 29(11):2009-15. PMID: 12897995.
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    155. van der Marel CD, Anderson BJ, van Lingen RA, Holford NH, Pluim MA, Jansman FG, van den Anker JN, Tibboel D. Paracetamol and metabolite pharmacokinetics in infants. Eur J Clin Pharmacol. 2003 Jul; 59(3):243-51. PMID: 12761605.
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    156. de Hoog M, Mouton JW, van den Anker JN. Thoughts on "Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates". Ther Drug Monit. 2003 Apr; 25(2):256-7; author reply 257. PMID: 12657925.
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    157. Lowry JA, Kearns GL, Abdel-Rahman SM, Nafziger AN, Khan IS, Kashuba AD, Schuetz EG, Bertino JS, van den Anker JN, Leeder JS. Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo. Clin Pharmacol Ther. 2003 Mar; 73(3):209-22. PMID: 12621386.
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    158. 't Jong GW, Eland IA, Sturkenboom MC, van den Anker JN, Stricker BH. Determinants for drug prescribing to children below the minimum licensed age. Eur J Clin Pharmacol. 2003 Feb; 58(10):701-5. PMID: 12610748.
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    159. de Hoog M, van Zanten BA, Hop WC, Overbosch E, Weisglas-Kuperus N, van den Anker JN. Newborn hearing screening: tobramycin and vancomycin are not risk factors for hearing loss. J Pediatr. 2003 Jan; 142(1):41-6. PMID: 12520253.
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    160. de Wildt SN, Kearns GL, Sie SD, Hop WC, van den Anker JN. Pharmacodynamics of intravenous and oral midazolam in preterm infants. Clin Drug Investig. 2003; 23(1):27-38. PMID: 23319091.
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    161. van Schaik RH, van der Heiden IP, van den Anker JN, Lindemans J. CYP3A5 variant allele frequencies in Dutch Caucasians. Clin Chem. 2002 Oct; 48(10):1668-71. PMID: 12324482.
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    162. 'T Jong GW, Eland IA, Sturkenboom MC, van den Anker JN, Stricker BH. Unlicensed and off label prescription of drugs to children: population based cohort study. BMJ. 2002 Jun 01; 324(7349):1313-4. PMID: 12039827; PMCID: PMC113770.
    163. van den Anker JN. Molecular epidemiology of antibiotic-resistant Gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period. Pediatrics. 2002 Jun; 109(6):1187-8; author reply 1187-8. PMID: 12042570.
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    164. de Hoog M, Schoemaker RC, van den Anker JN, Vinks AA. NONMEM and NPEM2 population modeling: a comparison using tobramycin data in neonates. Ther Drug Monit. 2002 Jun; 24(3):359-65. PMID: 12021626.
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    165. de Hoog M, Mouton JW, Schoemaker RC, Verduin CM, van den Anker JN. Extended-interval dosing of tobramycin in neonates: implications for therapeutic drug monitoring. Clin Pharmacol Ther. 2002 May; 71(5):349-58. PMID: 12011820.
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