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Shi, Dashuang (daniel)

TitleAssociate Research Professor
InstitutionChildrens National Medical Center
DepartmentCenter for Genetic Medicine
Address111 Michigan Ave NW
Washington DC 20010
Phone(202) 4765817
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shi D, Zhao G, Ah Mew N, Tuchman M. Precision medicine in rare disease: Mechanisms of disparate effects of N-carbamyl-l-glutamate on mutant CPS1 enzymes. Mol Genet Metab. 2017 Mar; 120(3):198-206. PMID: 28007335.
      View in: PubMed
    2. Shi D, Allewell NM, Tuchman M. From Genome to Structure and Back Again: A Family Portrait of the Transcarbamylases. Int J Mol Sci. 2015 Aug 12; 16(8):18836-64. PMID: 26274952; PMCID: PMC4581275.
    3. Shi D, Allewell NM, Tuchman M. The N-Acetylglutamate Synthase Family: Structures, Function and Mechanisms. Int J Mol Sci. 2015 Jun 09; 16(6):13004-22. PMID: 26068232; PMCID: PMC4490483.
    4. Li Y, Li P, Peng Y, Wu Q, Huang F, Liu X, Li X, Zhou H, Guo D, Shi D, Zhou XN, Fan X. Expression, characterization and crystal structure of thioredoxin from Schistosoma japonicum. Parasitology. 2015 Jul; 142(8):1044-52. PMID: 25810021.
      View in: PubMed
    5. Zhao G, Jin Z, Allewell NM, Tuchman M, Shi D. Structures of the N-acetyltransferase domain of Xylella fastidiosa N-acetyl-L-glutamate synthase/kinase with and without a His tag bound to N-acetyl-L-glutamate. Acta Crystallogr F Struct Biol Commun. 2015 Jan 01; 71(Pt 1):86-95. PMID: 25615976; PMCID: PMC4304755.
    6. Jimenez-Morales D, Adamian L, Shi D, Liang J. Lysine carboxylation: unveiling a spontaneous post-translational modification. Acta Crystallogr D Biol Crystallogr. 2014 Jan; 70(Pt 1):48-57. PMID: 24419378; PMCID: PMC3919261.
    7. Li Y, Wu Q, Peng Y, Huang F, Li X, Chen L, Shi D, Zhou X, Fan X. Expression, crystallization and preliminary X-ray diffraction analysis of thioredoxin glutathione reductase from Schistosoma japonicum in complex with FAD. Acta Crystallogr F Struct Biol Commun. 2014 Jan; 70(Pt 1):92-6. PMID: 24419626; PMCID: PMC3943093.
    8. Zhao G, Jin Z, Allewell NM, Tuchman M, Shi D. Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. PLoS One. 2013; 8(7):e70369. PMID: 23894642; PMCID: PMC3722096.
    9. Zhao G, Jin Z, Wang Y, Allewell NM, Tuchman M, Shi D. Structure and function of Escherichia coli RimK, an ATP-grasp fold, L-glutamyl ligase enzyme. Proteins. 2013 Oct; 81(10):1847-54. PMID: 23609986.
      View in: PubMed
    10. Zhao G, Haskins N, Jin Z, M Allewell N, Tuchman M, Shi D. Structure of N-acetyl-L-glutamate synthase/kinase from Maricaulis maris with the allosteric inhibitor L-arginine bound. Biochem Biophys Res Commun. 2013 Aug 09; 437(4):585-90. PMID: 23850694; PMCID: PMC3754781.
    11. Zhao G, Allewell NM, Tuchman M, Shi D. Structure of the complex of Neisseria gonorrhoeae N-acetyl-L-glutamate synthase with a bound bisubstrate analog. Biochem Biophys Res Commun. 2013 Jan 25; 430(4):1253-8. PMID: 23261468; PMCID: PMC3558559.
    12. Wei J, Xue Y, Wu L, Ma J, Yi X, Zhang J, Lu B, Li C, Shi D, Shi S, Feng X, Cai T. Analysis of large phenotypic variability of EEC and SHFM4 syndromes caused by K193E mutation of the TP63 gene. PLoS One. 2012; 7(5):e35337. PMID: 22574117; PMCID: PMC3344828.
    13. Shi D, Yu X, Zhao G, Ho J, Lu S, Allewell NM, Tuchman M. Crystal structure and biochemical properties of putrescine carbamoyltransferase from Enterococcus faecalis: Assembly, active site, and allosteric regulation. Proteins. 2012 May; 80(5):1436-47. PMID: 22328207; PMCID: PMC3526856.
    14. Shi D, Li Y, Cabrera-Luque J, Jin Z, Yu X, Zhao G, Haskins N, Allewell NM, Tuchman M. A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. PLoS One. 2011; 6(12):e28825. PMID: 22174908; PMCID: PMC3236213.
    15. Li Y, Jin Z, Yu X, Allewell NM, Tuchman M, Shi D. The ygeW encoded protein from Escherichia coli is a knotted ancestral catabolic transcarbamylase. Proteins. 2011 Jul; 79(7):2327-34. PMID: 21557323; PMCID: PMC3115391.
    16. Li Y, Yu X, Ho J, Fushman D, Allewell NM, Tuchman M, Shi D. Reversible post-translational carboxylation modulates the enzymatic activity of N-acetyl-L-ornithine transcarbamylase. Biochemistry. 2010 Aug 17; 49(32):6887-95. PMID: 20695527; PMCID: PMC2959125.
    17. Caldovic L, Ah Mew N, Shi D, Morizono H, Yudkoff M, Tuchman M. N-acetylglutamate synthase: structure, function and defects. Mol Genet Metab. 2010; 100 Suppl 1:S13-9. PMID: 20303810; PMCID: PMC2876818.
    18. Min L, Jin Z, Caldovic L, Morizono H, Allewell NM, Tuchman M, Shi D. Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine. J Biol Chem. 2009 Feb 20; 284(8):4873-80. PMID: 19095660; PMCID: PMC2643497.
    19. Shi D, Sagar V, Jin Z, Yu X, Caldovic L, Morizono H, Allewell NM, Tuchman M. The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation. J Biol Chem. 2008 Mar 14; 283(11):7176-84. PMID: 18184660; PMCID: PMC4099063.
    20. Shi D, Yu X, Cabrera-Luque J, Chen TY, Roth L, Morizono H, Allewell NM, Tuchman M. A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase. Protein Sci. 2007 Aug; 16(8):1689-99. PMID: 17600144; PMCID: PMC2203365.
    21. Qu Q, Morizono H, Shi D, Tuchman M, Caldovic L. A novel bifunctional N-acetylglutamate synthase-kinase from Xanthomonas campestris that is closely related to mammalian N-acetylglutamate synthase. BMC Biochem. 2007 Apr 10; 8:4. PMID: 17425781; PMCID: PMC1865377.
    22. Shi D, Caldovic L, Jin Z, Yu X, Qu Q, Roth L, Morizono H, Hathout Y, Allewell NM, Tuchman M. Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 01; 62(Pt 12):1218-22. PMID: 17142901; PMCID: PMC2225375.
    23. Shi D, Yu X, Roth L, Morizono H, Tuchman M, Allewell NM. Structures of N-acetylornithine transcarbamoylase from Xanthomonas campestris complexed with substrates and substrate analogs imply mechanisms for substrate binding and catalysis. Proteins. 2006 Aug 01; 64(2):532-42. PMID: 16741992.
      View in: PubMed
    24. Shi D, Yu X, Roth L, Tuchman M, Allewell NM. Structure of a novel N-acetyl-L-citrulline deacetylase from Xanthomonas campestris. Biophys Chem. 2007 Mar; 126(1-3):86-93. PMID: 16750290.
      View in: PubMed
    25. Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M. Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis. J Biol Chem. 2006 Jul 21; 281(29):20623-31. PMID: 16704984.
      View in: PubMed
    26. Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M. Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis. J Bacteriol. 2006 Apr; 188(8):2974-82. PMID: 16585758; PMCID: PMC1446984.
    27. Caldovic L, Lopez GY, Haskins N, Panglao M, Shi D, Morizono H, Tuchman M. Biochemical properties of recombinant human and mouse N-acetylglutamate synthase. Mol Genet Metab. 2006 Mar; 87(3):226-32. PMID: 16321554.
      View in: PubMed
    28. Shi D, Yu X, Roth L, Morizono H, Hathout Y, Allewell NM, Tuchman M. Expression, purification, crystallization and preliminary X-ray crystallographic studies of a novel acetylcitrulline deacetylase from Xanthomonas campestris. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 01; 61(Pt 7):676-9. PMID: 16511126; PMCID: PMC1952451.
    29. Caldovic L, Morizono H, Panglao MG, Lopez GY, Shi D, Summar ML, Tuchman M. Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. Hum Mutat. 2005 Mar; 25(3):293-8. PMID: 15714518.
      View in: PubMed
    30. Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M. Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria. J Biol Chem. 2005 Apr 15; 280(15):14366-9. PMID: 15731101.
      View in: PubMed
    31. Morizono H, Caldovic L, Shi D, Tuchman M. Mammalian N-acetylglutamate synthase. Mol Genet Metab. 2004 Apr; 81 Suppl 1:S4-11. PMID: 15050968; PMCID: PMC3031861.
    32. Caldovic L, Morizono H, Gracia Panglao M, Gallegos R, Yu X, Shi D, Malamy MH, Allewell NM, Tuchman M. Cloning and expression of the human N-acetylglutamate synthase gene. Biochem Biophys Res Commun. 2002 Dec 13; 299(4):581-6. PMID: 12459178.
      View in: PubMed
    33. Shi D, Gallegos R, DePonte J, Morizono H, Yu X, Allewell NM, Malamy M, Tuchman M. Crystal structure of a transcarbamylase-like protein from the anaerobic bacterium Bacteroides fragilis at 2.0 A resolution. J Mol Biol. 2002 Jul 19; 320(4):899-908. PMID: 12095263.
      View in: PubMed
    34. Caldovic L, Morizono H, Yu X, Thompson M, Shi D, Gallegos R, Allewell NM, Malamy MH, Tuchman M. Identification, cloning and expression of the mouse N-acetylglutamate synthase gene. Biochem J. 2002 Jun 15; 364(Pt 3):825-31. PMID: 12049647; PMCID: PMC1222632.
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